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Some users of Curvelle have reported side effects that include upset stomach and jitteriness. Diet pills may contain ingredients that interact with other medications. If taking prescription drug or herbal medications, consult a medical professional for advice before taking Curvelle. Weight loss pills such as Curvelle are not FDA-approved for weight loss. Curvelle contains caffeine. Since caffeine is a stimulant, do not take Curvelle within 4 hours of sleeping. If taking Curvelle, reduce caffeine intake from other sources. Too much caffeine can cause nervousness, jittery feelings and heart palpitations.

What is Curvelle?

Curvelle is a fat burner designed specifically for women. Curvelle claims to control sugar cravings, burn excess calories and contain antioxidants to enhance health and radiance. Although the manufacturer claims that Curvelle is an effective fat burner and appetite suppressant, the ingredients do not appear particularly potent.

See also: Curvelle Fat Burner for Women

Curvelle ingredients

Curvelle contains a proprietary blend of 683 mg of ingredients that include:

Cinnulin PF: An extract from cinnamon bark that is believed to be able to balance the sugar levels in the bloodstream. Stabilization of insulin function is of great importance to slimmers. It is rapidly fluctuating blood sugar levels and the subsequent craving for sweet foods that hampers the efforts of many dieters. High doses of cinnamon have actually been demonstrated to be toxic, but Cinnulin PF has been tested clinically and shown to be safe to ingest daily.

Green tea: Contains caffeine that speeds up the body’s metabolic rate. The combination of green tea (standardized for caffeine and ECGC) and caffeine has been demonstrated to promote weight loss (Obes Res. 2005; 13: 1195-204). Users sensitive to caffeine could experience any of the following side effects: restlessness, irritability, sleeping problems, tremors, heart palpitations, loss of appetite, upset stomach, nausea, frequent urination and skin rash.

Razberi K: This compound is a ketone found in red raspberries. It is believed to help reduce body fat by decreasing dietary fat absorption in the small intestine, and stimulate increased production of the neurotransmitter norepinephrine which promotes the breakdown of fat stored in cells. There are no reported side effects in taking Razberi K.

Slow release natural caffeine: This variant of caffeine is incorporated in Curvelle. As good as this may be, dieters who are especially sensitive to caffeine should be careful when considering using Curvelle. This diet pill contains caffeine at a dosage equivalent to 3 cups of coffee. Excess caffeine may cause jitters, insomnia, headaches, increased heart rate and blood pressure.

Elderberry extract: This extract is rich in anthocyanins and antioxidants which have been shown to improve health and help fight oxidative stress in the body. There are no recognized adverse effects, although data is limited. It is suggested that a diuretic of elderberry extract may result in hypokalemia, but this has not been scientifically studied. There are no recognized drug interactions in taking elderberry extract. The stems, roots, unripe berries, and seeds may contain cyanide, and could cause vomiting and severe diarrhea if chewed or eaten uncooked. Ripe berries are safe when prepared for use in foods.

Curvelle dosage

Each container of Curvelle contains 100 capsules. Isotori, the manufacturers of this product, suggest taking two capsules before breakfast and lunch, as well as two before exercise.

There are several stimulants in the weight loss formula of the Fat Burner by Size 0 Labs. The caffeine, green coffee bean, green tea and Cha de Bugre all include stimulants that have been reported to cause jitters, headaches, nausea, stomach problems and other health issues in some users.

See also: Size 0 Fat Burner Review

Size 0 ingredients

The relevant weight loss ingredients in Size 0 are as follows:

Caffeine anhydrous: This compound is a thermogenic agent with clinically proven benefits for weight loss. Caffeine may cause jitters, insomnia, headaches, increased heart rate and raised blood pressure.

Green tea extract: There is evidence to indicate that green tea offers benefits to dieters. Studies have shown that the tea can elevate metabolism and inhibit the action of the enzyme amalyse. Users sensitive to caffeine could experience any of the following side effects: restlessness, irritability, sleeping problems, tremors, heart palpitations, loss of appetite, upset stomach, nausea, frequent urination and skin rash.

Green Coffee Bean Extract: Coffee made from green, unroasted coffee beans has recently been found to promote weight loss. The discovery parallels earlier research on green tea. Green coffee appears to have a more potent effect. There are two key types of compounds in unroasted coffee beans. The first is caffeine and the second is chlorogenic acid and its related compounds. Heating destroys the acids. Currently, there are no clinical studies on green coffee extract’s weight loss effects on humans. In human trials, no significant adverse effects have been seen. In theory, the caffeine content of green coffee bean extract could potentially cause problems for some people. However, since the compound only contains about 10% caffeine by weight, a high daily dose contains no more than about 20% of the caffeine content of a strong cup of coffee. Maximum safe doses in pregnant or nursing women, young children, or people with liver or kidney disease have not yet been established.

Naringin Citrus Extract: A powerful bioflavanoid found in grapefruit, giving it its bitter flavor. Naringin works synergistically with other nutrients, increasing their bio-availability and extending their effects in the body. This citrus extract also interferes with enzyme activity in the intestines, and therefore can inhibit the breakdown of certain drugs. Naringin has been shown to be non-toxic at levels many times greater than the recommended dosages. Even when taken daily, naringin seldom produces a significant allergic reaction. However, people who are allergic to citrus fruits should exercise caution in the use of naringin.

Cordia Salisifolia Extract: This extract, also known as Cha de Bugre, is becoming a common ingredient in weight loss products and supplements. While no significant side effects have been reported Cha de Bugre does contain caffeine.

Also present is cocoa extract, probably included as a mood enhancer.

In addition to the thermogenic complex in Size 0, there are three additional complexes:

Appetite Support Complex: A blend of Hoodia gordonii, jojoba seed extract and Griffonia simplicifolia seed extract.

Beauty Support Blend: A blend of biotin, collagen, choline, horsetail leaf extract, hyaluronic acid, inositol, l-cycsteine, l-methionine, coenzyme Q10, silica, and chamomile flower leaf extract.

Estrogen Support Complex: A blend of chaste tree berry, daidzen, dong quai root and vitex agnus castus.

Size 0 recommended dosage

Each bottle of Size 0 contains 100 tablets As a dietary supplement, the manufacturers recommend taking 1-2 tablets, 2-3 times daily, 30 minutes before eating, with 16 oz of water. Begin use with a lower dose to assess tolerance.

More and more women are using Clenbuterol, which is commonly called “Clen”, to lose weight quickly. Fore some, this could be a potentially life threatening decision. Even short-term usage of Clenbuterol is known to produce side-effects such as headaches, muscle tremors, insomnia, restlessness, palpitations, increased perspiration, muscle spasms, increased blood pressure, and nausea. Long-term consumption of Clenbuterol may lead to serious health problems. Permanent side effects, such as left-sided cardiac atrophy, can occur very quickly; in as little as one month in some cases when Clenbuterol is taken in high doses.

See also related article: Clenbuterol and Weight Loss

What is Clenbuterol?

Recently, the media have been reporting on the revelation that, for well over a decade, celebrities have been using Clenbuterol. Clenbuterol HCL, also known as Clenbuterol Hydrochloride, Ventipulmin, Spiropent, Novegam and Oxyflux, is a drug that is growing in popularity as an illegal diet pill.

Clenbuterol was initially developed to alleviate asthma symptoms in horses by relaxing the muscles in the airways. Its stimulant effect on the heart and central nervous system is comparable with adrenalin or amphetamines.

Clenbuterol is illegal in the US for human use. This is due to the fact that the drug has side-effects, such as palpitations and arrhythmia [irregular heartbeat], and has been linked to several cases of poisoning. In the US and most countries in Europe, Clenbuterol is prohibited for use in animals that will enter the food chain.

Although many dieters would like to use Clenbuterol for weight loss indefinitely, the drug is rarely taken for more than a month at a time. This is due to progressive loss of effectiveness. It is believed that this reduction in efficacy is due to a drug induced decline in the number of beta-2 receptors in the body over time, making Clenbuterol less potent. If the dose is increased, little additional benefit is achieved and side-effects become a major problem.

Side-effects of Clenbuterol

Clenbuterol is usually only effective for around 4 weeks. Thereafter, the body develops resistance to the drug. Short-term usage of Clenbuterol is known to produce side-effects. These side-effects are usually short-lived and often subside after 8-10 days, despite continued use of the drug. Side-effects of Clenbuterol are dose-dependant and include:

• Headaches
• Light-headiness
• Dizziness
• Pallor
• Heartburn
• Weakness
• Paradoxical bronchospasm
• Dysuria
• Dry mouth
• Muscular tremors (especially hand shakes)
• Muscular cramps
• Nervousness
• Insomnia
• Facial flushing
• Sweating
• Increased appetite
• Nausea and vomiting
• Chest pain
• Palpitations
• Tachycardia
• Hypertension (high blood pressure)
• Possible cardiac hypertrophy
• Heart muscle necrosis has been demonstrated in animal studies

After ingestion, Clenbuterol remains in the body for up to 39 hours. As a result of its long residence time, the adverse effects of Clenbuterol can be prolonged. Long-term consumption of Clenbuterol may lead to serious health problems. Permanent side effects, such as left-sided cardiac atrophy, can occur very quickly; in as little as one month in some cases when Clenbuterol is taken in high doses.

Clenbuterol overdose

Other side-effects can develop rapidly when overdosing on the drug: sudden racing heart beat (tachycardia), irregular heart beat (arrhythmia), depleted phosphate levels, potassium depletion, taurine depletion, headaches, tremors, vertigo and even stroke. Liver damage is also possible. Sudden death is possible at very high doses of Clenbuterol.

Symptoms may begin within minutes of ingestion of Clenbuterol at high doses, and last for hours/ days leading to prolonged toxicity due to the long-half life of the drug.

Because Clenbuterol can increase muscle definition and reduces fat, livestock are often dosed with the drug. In Spain in 1994, 140 people were hospitalised after they consumed meat tainted with Clenbuterol. They suffered dizziness, heart palpitations, breathing difficulties, shakes and headaches. In China recently, the newspaper People’s Daily reported that 336 people in Shanghai had been poisoned after eating pork contaminated with Clenbuterol. The drug had been banned by the Chinese government in the 1990s.

Clenbuterol interaction with other drugs

Caution is advised when using Clenbuterol in combination with other adrenoceptor agonists, as side effects are likely to be cumulative. It is for this reason that it is not recommended to use ephedrine/ephedra (or ma huang) or the ECA stack (ephedrine-caffeine-aspirin) whilst taking Clenbuterol.

Clenbuterol studies in rats

Researchers at the University of Melbourne in Australia recently gave Clenbuterol to laboratory rats at a dose of 2 milligrams per kilogram of body weight per day.
After only 4 weeks, Clenbuterol-treated rats were unable to maintain the activity levels of normal untreated rats. The hearts of the Clenbuterol-treated rats increased dramatically in size compared to untreated rats, but unfortunately heart growth was probably due to the infiltration of collagen fibres into the heart walls, not to an increase in heart-muscle cell size and density. Collagen is a tough connective tissue which stiffens the organs in which it grows. In the case of the heart, the presence of collagen fibers would lead to a decrease in cardiac output. Increases in collagen may also result in cardiac arrhythmias. Clenbuterol treated rats also suffered from noticeable cardiac-cell degeneration.

Clenbuterol and Weight Gain

Despite the fact that the list of potential side-effects induced by Clenbuterol is extensive, there is one side-effect that is probably of key interest to slimmers. In the long-term Clenbuterol is known to suddenly lose its efficacy and can cause rapid weight gain - possibly due to a sudden slowing in the body’s metabolic rate.

Clenbuterol dosage

Clenbuterol can be administered as an inhaler spray, orally and intravenously. It is usually taken orally by slimmers and bodybuilders in dosages ranging between 20 and 60 micrograms a day. Users who have never taken Clenbuterol before, or users who have been off the drug for several weeks or months, typically start with one 20 milligram pill. Starting Clenbuterol at higher doses may induce noticeable side-effects.

Generally, Clenbuterol is gradually increased, depending on how well it is tolerated. The highest typical daily dose range is two to four tablets (40-80 micrograms) for women and two to eight tablets (40-160 micrograms) for men.

The information presented in this article is strictly for educational purposes only and is not intended to replace the advice or attention of healthcare professionals.

Reported side effects from taking Hot Rox Extreme weight loss pills include the jitters, rash, headaches, insomnia, hot flashes, severe nausea and dizziness. The manufacturer recommends that that pregnant or breast feeding women should not take Hot Rox Extreme. Those who are elderly or chronically ill should also avoid Hot Rox Extreme. Due to the presence of piperine in Hot Rox Extreme, patients taking medications should avoid this supplement.

The Food and Drug Administration have not evaluated or issued statements on many of the ingredients in Hot Rox Extreme, and clinical studies have not been carried out on the product itself or potential interactions with prescription drugs. It is therefore not advisable to take Hot Rox Extreme without consulting a medical practitioner.

How does Hot Rox Extreme work?

Hot Rox Extreme by Biotest is claimed to increase fat loss by up to 500%. It is said to achieve this by using a proprietary thermogenic formula which consists mainly of substances that increase lipase activity. Biotest heavily promote the apparent, ‘feel good’ effect after taking Hot Rox Extreme. This weight loss product is one of the latest generation of ephedra-free fat burners.

Hot Rox Extreme Dosage

Each bottle of Hot Rox Extreme contains 110 capsules. It is recommended to take 1 or 2 capsules of Hot Rox Extreme in the morning prior to breakfast and 1 or 2 capsules six hours later, each time on an empty stomach with 8 oz. of water. If a first time user of Hot Rox Extreme supplement, then begin by taking 1 capsule twice per day for 3 days prior to increasing the dose. Do not exceed 4 capsules in any 24-hour period. For best results, the manufacturer recommends taking Hot Rox Extreme for at least 1 month. If you have trouble sleeping, do not take Hot Rox Extreme within 6 hours of bedtime.

Ingredients of Hot Rox Extreme

There are two main active ingredients in Hot Rox Extreme: A7-E Super-Thermogenic Gel XXX500 and sclaremax, with guggulsterone functioning as a ‘booster’. Other ingredients include Carbolin™ 19, piperine, Yohimbine HCl, and caffeine.

A7-E Super-Thermogenic Gel: The website claims that A7-E is the longest lasting fat burning ingredient known to science. Biotest states that they have tested A7-E on human subjects, yet no clinical trial findings have been published.

Carbolin™ 19 (forskolin 1,9-carbonate): This is one of the ingredients incorporated in A7-E. Biotest claims that Carbolin 19 is a highly pure version of forskolin, which can help the body gain muscle mass. Unfortunately, the amount of forskolin in Carbolin 19, is not revealed.

Piperine: This compound is the alkaloid that makes black pepper so pungent. If any of the ingredients in Hot Rox Extreme Pills work the way that Biotest claims, then the addition of piperine could be helpful. Unfortunately, this compound could inhibit the metabolism of other drugs. In doing so, it may increase the bioavailability of other compounds, so a physician should be consulted prior to taking this weight loss supplement.

Yohimbine HCl: Biotest claims that Yohimbine HCl can block receptors that can make stubborn areas of the body resistant to fat loss. They present Yohimbine HCl as a fat spot reducer. A study conducted by the Institute of Sport Medicine, Sports Academy Belgrade did in fact find that Yohimbine HCl can reduce body fat in athletes. Yohimbine HCL may have excellent antioxidant potential. It is also believed to function as a vasodilator, boosting blood flow to the body’s extremities. As such, it has traditionally been used to treat erectile dysfunction. Do not use this ingredient is you have any form of hypertension.

Caffeine: The amount of caffeine in Hot Rox Extreme is not given. This is a cause for concern. Caffeine is a thermogenic compound. It has been shown to increase adrenaline levels; this hormone increases alertness and boosts energy levels. If sensitive to caffeine, potential side-effects can include: restlessness, irritability, sleeping problems, tremor, heart palpitations, upset stomach, nausea, frequent urination and skin rash.

Guggulsterones: Derived from the Indian Guggul tree, these compounds stimulate the thyroid gland to produce more thyroxin. This has the effect of increasing the body’s metabolic rate and, as a consequence, more fat is burnt. Some users have experienced gastrointestinal discomfort in taking guggulsterones.

Sclaremax: This compound is a diterpenoidal lactone found in a plant called Salvia sclarea. It is known to be an extremely potent adenylate cyclase activator, very similar to that of the diterpene derivative, forskolin, but with a much longer active life. The end result in taking this compound is stimulation of increased thyroid hormone production.

N-Acetyl-L-tyrosine: This is the amino acid tyrosine in free (unbound) form. Tyrosine is an amino acid that plays an important role in metabolism. It is the precursor to stimulatory neurotransmitters such as epinephrine, norepinephrine, dopamine and some of the thyroid hormones. All of these neurotransmitters and hormones play important roles in maintaining the body’s metabolic rate. Increased levels of tyrosine in the body can increase meatabolic rate. Several studies have also shown that tyrosine increases the benefits of caffeine/ephedrine products, in part by curbing appetite. The amount of L-tyrosine in Hot-Rox is not indicated on the product label. Toxicological studies indicate that tyrosine is quite safe.

Raspberry ketone: This is an aromatic compound found in red raspberries. Raspberry ketone has been shown to stimulate lipolysis in both white and brown adipose tissue.

The Hot Rox Extreme website

The Hot Rox Extreme website (Biotest.net) is a typical bodybuilding supplement website. It does, however, provide an ingredients label and a brief description of the product and some of its ingredients.

Hot Rox Extreme Pros

• Ephedra-free

Hot Rox Extreme Cons

• Contains caffeine
• Unsubstantiated claims
• On the expensive side
• Numerous negative customer testimonials
• There is not a 100% money-back guarantee with this product
• Propriety blend (ingredient amounts are not given)

Hot Rox Extreme Conclusions

Hot Rox Extreme is designed primarily for the bodybuilding community, and as such, should be avoided by the average person seeking to lose weight. Hot Rox Extreme has not yet been validated for safe use in man. There are no published clinical studies on this product.

Other Common Names: Biotest Hot Rox, Hot Rox Thermogenix, HotRox

Fenterdren is a fat burning diet pill that contains the stimulants synephrine, phenylethyamine and dicaffeine malate. The chemical make-up of synephrine is similar to ephedra and has been linked to a number of negative side effects including headaches, dizziness, elevated blood pressure and increased heart rate. Additionally, when added to other caffeine sources within the same product, it can further amplify these negative side effects. The makers of Fenterdren warn that users should not exceed the recommend dosage.

Another area of concern with Fenterdren is its combination of synephrine, phenylethylamine and dicaffeine malate. Research has shown that when these stimulating ingredients are combined, it can lead to adverse side-effects. These include anxiety, nervousness, insomnia, increased blood pressure, heart tremors and palpitations.

Fenterdren dosage

One bottle of Fenterdren 90 capsules and provides a one and a half month supply. The manufacturer recommends taking one capsule of Fenterdren with a full glass of water approximately thirty minutes before breakfast and one capsule with a full glass of water approximately thirty minutes before lunch. An intake of two capsules should not be exceeded in a 24 hour period.

Fenterdren ingredients

The ingredients in Fenterdren are synephrine (37.5 mg), phenylethyamine (37.5 mg) and dicaffeine malate (375 mg).

Dicaffeine malate: The compound may cause jitters, insomnia, headaches, increased heart rate and blood pressure. With 375 mg of caffeine, or the equivalent of nearly 4 cups of coffee, per capsule the effects of taking Fenterdren will certainly be felt. Originally used by the Coca Cola Company as an alternative to cocaine, DiCaffeine Malate is a stimulant-based ingredient used in soft drinks, energy drinks and dietary supplements. It combines natural caffeine with malic acid. The combination forms an ionic bonded compound which is gentle on the stomach and is claimed to optimize energy, stimulate thermogenesis and increase mental focus.

Synephrine: Since synephrine acts as a stimulant it is not recommended for individuals who are sensitive to caffeine, and those who have history of heart problems, high blood pressure and thyroid problems. Side effects of synephrine may include: rapid increases in blood pressure, cardiac arrhythmias, respiratory problems, dizziness, headaches, tremors, low blood sugar, blood sugar imbalances, flushing of the skin, restlessness and agitation, These side effects are all similar in scope to ephedrine and ephedra-based diet drugs that are now banned from the market.

At first, synephrine looked like it might be an alternative to ephedra. However, since that time, clinical research has shown that synephrine demonstrates relatively minor weight loss effects. Synephrine is a drug that releases adrenaline and noradrenalin the body in order to stimulate the metabolism. The compound is derived from the fruit of Citrus aurantium, and is usually listed as Bitter Orange, Zhishi, and Sour Orange in ‘natural’ weight loss products.

Ongoing research and clinical trials will provide more information on the long-term effects of syneprhine, but until then, there is no conclusive evidence that the drug is safe. Almost all diet pills that contain synephrine have not been approved by the FDA.

Phenylethylamine (PEA): PEA should not to be taken with MAO (mono amine oxidase) inhibitor drugs. MAO inhibitors are a potent class of medications used to treat depression. If you are pregnant or breastfeeding or are being treated for depression or other neurological conditions you should consult your health care professional before using this product.

PEA is becoming a popular ingredient in weight loss supplements. This endogenous neuroamine is found in chocolate, certain algae and is produced in the brain from the amino acid D-Phenylalanine. It improves mood very rapidly and has been called the ‘Love Chemical’ because of its effect on beta endorphins, an opioid peptide responsible for pleasurable feelings. Due to it neuro-modulating actions it plays a key role in the feed/reward mechanisms of dietary behavior. In reality, phenylethylamine is metabolized by the enzyme monamine oxidase, and very little ingested PEA actually reaches the brain. However, if very high concentrations of PEA it can reach the brain in quantities sufficient to mimic amphtamine.

A fat burner is a dietary supplement that can contain herbs, plant extracts and/ or chemicals that may stimulate metabolism, and/or suppress appetite. Finding the ‘right’ fat burner is often difficult.

A key thing to bear in mind when using fat burning supplements is that they are just that – Supplements! Supplements are used to supplement or assist your diet and exercise program.

There are many postings on the internet from people who have been disappointed in their fat burner. It may be that the ingredients in the pills that they were taking were not up to the job. But often the problem can lay with the people taking the pills. Without an exercise routine and a healthy diet most fat burners will have little effect.

If a good fat burner is used correctly you will see results. Here are some tips to help you get more out of your fat burner.

• Persevere. Do not expect instant results.

• If you are tempted by after meal deserts, make them low fat.

• Do not use your fat burner as an excuse for eating bigger portions.

• Do not exceed the recommended dose.

• Do not take the fat burner indefinitely.