Xyphedrex Side Effects

Xyphedrex is a fat burning and energy boosting formulation offering 4 major ingredients. Unfortunately, there is no meaningful clinical data supporting the product posted on the official website. Xyphedrex is a stimulant heavy pill and side effects can include headaches, jitteriness, nervousness, irritability, insomnia and elevated heartbeat.

Related article: Xyphedrex Review

Xyphedrex pros

  • Xyphedrex comes with a money-back guarantee

Xyphedrex cons

  • Xyphedrex reviews are mixed with some users reporting no positive results with regard to weight loss
  • Xyphedrex is a stimulant heavy diet pill
  • Xyphedrex contains high levels of caffeine
  • Some users report experiencing side effects using Xyphedrex
  • No details are provided on where Xyphedrex is manufactured or the quality control procedures involved

Xyphedrex ingredients

Xyphedrex ‘s ingredients are:

  • Dicaffeine malate
  • Synephrine
  • Chocamine
  • Phenylethylamine
  • Gelatin
  • Magnesium stearate

Looking at the ingredients in greater detail:

Dicaffeine malate (200 mg): Originally used by the Coca Cola Company as an alternative to cocaine, DiCaffeine Malate is a stimulant-based ingredient used in soft drinks, energy drinks and dietary supplements. DiCaffeine Malate combines natural caffeine with Malic Acid. The combination forms an ionic bonded compound which is gentle on the stomach and is claimed to optimize energy, stimulate thermogenesis and increase mental focus. Many clinical studies have validated caffeine as an agent for boosting energy and helping with weight loss. However, there is no research supporting the fact that dicaffeine malate is any more effective than standard caffeine. DiCaffeine Malate may cause jitters, insomnia, headaches, increased heart rate and raised blood pressure.

Chocamine (200 mg): A proprietary extract of the cocoa plant. It contains numerous constituents including methylxanthines (theobromine, caffeine, and theophylline), biogenic amines (phenylethylamine and tyramine) amino acids (phenylalanine, tryptophan, tyrosine, others), minerals, numerous beneficial antioxidants, and possibly some non-psychoactive cannabanoid-related compounds. Chocamine produces a very smooth energy boost with no crash. This ingredient is not new to fat burners but does not actually promote weight loss. Chocamine contains caffeine, which can cause side effects (see above).

Phenylethylamine (20 mg): An alkaloid that functions as a neurotransmitter in the brain, and is believed to boost levels of dopamine. The increase in dopamine promotes a feeling of wellbeing. It is claimed to have appetite suppressing effects as well. Side effects of phenylalanine that are common but not serious include heartburn, nausea, constipation and mild headaches. Serious side effects associated with phenylalanine include insomnia, confusion, dizziness or intense headache. An individual experiencing these symptoms should consult with a physician before continuing phenylalanine doses. Severe side effects associated with phenylalanine include tightness or sharp pain in the chest, difficulty breathing and a sudden increase in heart rate or blood pressure. Symptoms of allergic reaction to phenylalanine include sudden rash or hives and swelling of the face, neck, lips or tongue. An individual experiencing these side effects should seek immediate emergency medical attention. Phenylalanine has the potential to adversely interact with antipsychotic medications prescribed to treat schizophrenia, depression and bipolar disorder such as thioridazine, clozapine and haloperidol. This may result in symptoms of tardive dyskinesia (involuntary movements of the limbs, facial muscles and tongue). Phenylalanine may also diminish the effectiveness of levodopa, a medication prescribed to ease the symptoms of Parkinson’s disease.

Synephrine HCL (20 mg): Synephrine is sourced from the Citrus aurantium plant. It can help promote fat burning, suppress appetite and increase energy. However, clinical studies have revealed that Citrus aurantium stimulates a relatively small increase in thermogenesis. Reported side effects of Synephrine include dry mouth, headache, nervousness, anxiety, insomnia, tremor, blurred vision, increased heart rate and blood pressure. Synephrine may also reduce the ability to urinate. It is advisable to consult a doctor if you have any history of high blood pressure, anxiety, urinary problems or cardiac disease. In addition, combining decongestants such as Synephrine with other medicines with similar side effects may lead to dangerous complications.

Xyphedrex dosage

A single bottle of Xyphedrex contains 60 capsules. The manufacturer recommends taking a single capsule 30 minutes before both breakfast and lunch. When used as directed, each bottle will last 1 month.

Xyphedrex conclusion

Although Xyphedrex does not contain ephedra, it is a stimulant heavy diet pill. If sensitive to stimulants, this is a weight loss product is best avoided.

MetaboSpeed XXX Side Effects

MetaboSpeed XXX, a diet pill marketed by Lab88, contains high levels of the stimulants Guarana and Bitter Orange. Side effects that may occur from taking MetaboSpeed XXX include constipation, dehydration, muscle cramps, nausea, stomach discomfort, restlessness, jitters, nervousness, irritability, insomnia, rapid heartbeat and high blood pressure. MetaboSpeed XXX has not been evaluated in clinical studies and there are few testimonials supporting it effectiveness as a weight loss product.

See also: MetaboSpeed Review

MetaboSpeed XXX side effects

Side effects that may occur from taking MetaboSpeed XXX include constipation, dehydration, muscle cramps, nausea, stomach discomfort, restlessness, jitters, nervousness, irritability, insomnia, rapid heartbeat and high blood pressure. MetaboSpeed XXX may interact with both prescription and over-the-counter drugs. The stimulants in MetaboSpeed XXX, namely Guarana extract, Green tea extract, Bitter Orange extract and Korean Ginseng, can cause over-stimulation of the circulatory system. This may counteract the effectiveness of drugs used to lower blood pressure. If suffering from hypertension consult a doctor before taking MetaboSpeed XXX. While using MetaboSpeed XXX it is advisable to limit the consumption of any food or beverages that contain caffeine. Do not take MetaboSpeed XXX if suffering from diabetes, high blood pressure, renal disease, spasms, migraines, hyperthyroidism, heart disease, psychiatric disorders, or are allergic to chocolate or tyramine. Do not combine MetaboSpeed XXX with asthma medications. Take advice from a doctor first, if taking monoamine oxidase inhibitors (MAOIs).

MetaboSpeed XXX pros

  • Some of MetaboSpeed XXX ingredients have been evaluated in clinical trials
  • Details of the manufacturer, the country where MetaboSpeed XXX is made, product quality control and purity and a contact address are given on the website

MetaboSpeed XXX cons

  • The MetaboSpeed XXX formulation is stimulant heavy
  • There are side effects associated with MetaboSpeed XXX
  • A significant component of the MetaboSpeed XXX formulation is a propriety blend. Are there high enough doses of the active ingredients for optimal weight loss effectiveness?

MetaboSpeed XXX ingredients

The ingredients in MetaboSpeed XXX are:

Guarana extract (800 mg): Guarana seeds contain five times more caffeine (caffeine is a thermogenic agent) than coffee beans. MetaboSpeed XXX has 800mg of Guarana extract standardized to 20% caffeine. In other words it contains 160mg of caffeine. Guarana is a popular ingredient in many stimulant-based weight loss pills. Guarana may cause side effects that can include: anxiety; diarrhea; headache; increased urination; nausea; nervousness; shakiness; tremors; trouble sleeping; upset stomach; and vomiting.

Bitter Orange extract (200 mg): This ingredient is an oil that is extracted from the Citrus aurantium fruit and is used for a variety of purposes in traditional Chinese medicine. It is a common ingredient in many diet pills. Bitter orange extract contains Synephrine, which is similar to ephedrine in that it raises blood pressure, heart rate and metabolism. Synephrine can help burn fat, suppress appetite and increase energy. However, clinical studies have revealed that Citrus aurantium induces a relatively modest increase in thermogenesis. Reported side effects include: increased heart rate and blood pressure, insomnia, nervousness, anxiety, tremor, dry mouth, blurred vision and headache. Synephrine may also reduce the ability to urinate. The adverse side effects of bitter orange can be exacerbated when used in combination with other stimulants such as caffeine, coffee, cola nut, Ephedra and Guarana. Consult a physician if you have any history of cardiac disease, high blood pressure, anxiety or urinary problems. Another potential problem with Citrus aurantium is that it could interact with a wide range of prescription drugs. Citrus aurantium inhibits an enzyme in the small intestine, known as CYP3A4, which can alter the metabolism of drugs and amplifying their activity. This enzyme is responsible for the metabolic activity of 50% of all prescription drugs.

Proprietary blend (160 mg): This low dose blend contains Green Tea, Vanadium, Garcinia cambogia, Ginseng, Bee Pollen and White Willow Bark.

Green tea: Green tea has been shown to promote modest weight loss. However, it needs to be taken in relatively high concentration, and to contain high levels of catechins. Users of green tea sensitive to caffeine could experience any of the following side effects: irritability, restlessness, nausea, insomnia, tremors, heart palpitations, upset stomach, frequent urination and skin rash.

Garcinia cambogia (standardized for hydroxycitric acid): Hydroxycitric acid (HCA), extracted from Garcinia cambogia, is claimed to suppress appetite and promote fat burning. Numerous studies have concluded that HCA causes no adverse side effects and that the quantity and quality of scientific evidence is sufficient to support the safe, supplemental use of HCA at doses of up to 2,800 mg daily. There are no known medication interactions associated with the use of HCA. However, patients taking oral hypoglycemic agents are advised to use caution before using HCA, due to the possibility of exacerbating the action of hypoglycemic medications. Consult a physician before commencing use. Individuals diagnosed with Diabetes mellitus should use extreme caution in taking HCA/Garcinia cambogia due to its glycemic action. Individuals with Alzheimer’s disease or other dementia syndromes should also avoid using HCA. Pending additional research HCA is viewed as safe and non-toxic for most healthy adult individuals.

Vanadium functions as an insulin mimic and has been shown to inhibit the synthesis of cholesterol. Although the use of high doses of vanadium supplements remains controversial, there are studies that suggest positive benefits in using vanadium to treat certain health conditions. For example, insulin sensitivity has been shown to improve in animals and human subjects treated with vanadium, suggesting that vanadium may be useful in helping to lower blood sugar levels in diabetics (e.g. Mol Cell Biochem. 2001; 218(1-2):93-96; Metabolism. 2001; 50(6):667-673). A clinical study has also shown a decrease in LDL (“bad”) cholesterol levels in diabetics taking vanadium supplements (J Clin Endocrinol Metab. 2001; 86(3):1410-1417). Long-term Vanadium use has not been studied, so the use of vanadium by diabetics should be avoided. Vanadium overdose has been associated with depression and mania. Individuals with a history of mood disorders should not use Vanadium supplements. Vanadium should never be taken in amounts greater than 1.8 mg/day. Side effects from Vanadium may include nausea, stomach upset, vomiting and diarrhea. High doses of vanadium can cause liver or kidney disease. Patients taking blood-thinning drugs such as Heparin should not use Vanadium, as it can potentiate the blood thinning effects of these drugs.

Metabo Speed XXX also contains phosphates which in one study, when combined with Garcinia cambogia, l-tyrosine and guggulsterones, promoted moderate weight loss. Unfortunately, neither l-tyrosine nor guggulsterones are present in the MetaboSpeed XXX formulation.

MetaboSpeed XXX dosage

Each bottle contains 60 pills or one months supply. Two pills are taken daily.

TestoRipped Side Effects


TestoRipped is blue diet pill for men. It offers 10 major ingredients to boost fat burning, muscle building, libido and energy. TestoRipped has a relatively high content of the stimulants Caffeine, Yohimbe and Synephrine. Side effects that have been reported using TestoRipped include: Stomach ache, headache, anxiety, jitters, nervousness, irritability, nausea, insomnia, racing heart, chest pains, spots, acne and increased appetite.

See also: TestoRipped review

TestoRipped pros

  • TestoRipped is reported to boost libido
  • The manufacturer recommends that TestoRipped is used in combination with a balanced diet and exercise
  • The effectiveness of TestoRipped is supported by positive reviews and testimonials

TestoRipped cons

  • Some users report no positive results using TestoRipped
  • TestoRipped is designed for men only
  • TestoRipped is a stimulant heavy diet pill
  • TestoRipped contains relatively high levels of caffeine
  • Many users have reported side effects using TestoRipped
  • TestoRipped does not have a money-back guarantee
  • There are no contact details for TestoRipped other than an email address – always a cause for concern
  • No details are provided on the country where TestoRipped is manufactured or the quality control procedures involved

TestoRipped dosage

A bottle of Testoripped contains 75 pills representing a 30 day dosage. Serving size is one capsule.

TestoRipped ingredients

TestoRipped’s ingredients are:

Arginine AKG (100 mg): Arginine Alpha Ketoglutarate (AAKG) has been shown to increase nitric oxide (NO) levels. NO is a molecule in the cardiovascular system that transports oxygen, increases blood flow and delivers nutrients to skeletal muscle. AKG helps increase workout performance, which can result in increased muscle mass. In a clinical trial, subjects taking four grams of AAKG three times a day reported no significant side effects, had no changes in blood pressure or heart rate, and exhibited no abnormalities on standard tests for general health (Vacanti et al. Sports Nutr Rev J. 2004;1:S10-S11). Some doctors believe that people with herpes (either cold sores or genital herpes) should not take arginine supplements, because of the possibility that it might stimulate replication of the virus. No clear interactions between AAKG and other nutrients have been established. At the time of writing, there are no obvious drug interactions with AAKG.

Caffeine (150 mg): This compound is incorporated into many weight loss supplements. Caffeine can cause anxiety, jitters, headaches, diarrhea, insomnia and increased heart rate.

Cinnamon Extract (50 mg): Cinnamon is one of the oldest remedies used in traditional Chinese medicine for digestive support. Cinnamon (Cinnamomum verum and Cinnamomum cassia) may have some benefit in lowering blood-sugar levels and may help slow the body’s absorption of fat. Research studies have yielded conflicting results and it is not yet clear whether taking a cinnamon supplement reduces blood sugar levels with long term use. Chronic extensive surface ulcerations and lip swelling induced by cinnamon have been reported (Cohen and Bhattacharyya. J Am Dent Assoc. 2000;131(7):929-934). Fourteen cases of cinnamon-induced stomatitis have also reported (Miller et al. Oral Surg Oral Med Oral Pathol. 1992;73(6):708-716.

Creatine Ethyl Ester (100 mg): Creatine is used as an aid for athletic performance and for muscle development in bodybuilding. Cramping and bloating are the most common side effects experienced by creatine users. However, with the more easily absorbed creatine ethyl ester form, these side effects may be eliminated or reduced.

Eurycoma longifolia (50 mg): Standardized for 40% glyco saponins and 30% polysacharides, the Eurycoma extract in TestoRipped has been shown to help increase IGF1 levels and modulate cortisol levels. Studies on this particular extract have shown that it increased the average male serum testosterone level by 100% after 2 weeks of use. One of the side effects of high dose Eurycoma root is that it can cause insomnia. Additional reported side effects are increased body temperature, restless and irritability.

L-Glutamine (100 mg): L-Glutamine is used by athletes and bodybuilders to help them recover faster from workouts and competition, and to keep muscles hydrated for maximum growth. However, to obtain optimal results from this compound a higher dose than 100 mg is required. No side effects have been reported for glutamine. This is not surprising considering the abundance of glutamine in the human body.

Guggulsterones 2.5% (15 mg): This ingredient is a patented extract of Commiphora mukul. Other common names are Gugalipids and Guggul. Studies have demonstrated that Guggal is safe and effective in lowering the various lipid fractions that are known to contribute to coronary heart disease.

Synephrine HCL (15 mg): Synephrine is derived from the Citrus aurantium plant. It can help boost fat burning, reduce appetite and increase energy. However, clinical studies have indicated that Citrus aurantium promotes a relatively small increase in thermogenesis. Side effects of Synephrine include dry mouth, headache, nervousness, anxiety, insomnia, tremor, blurred vision, increased heart rate and blood pressure. Synephrine may also make urination more difficult. Individuals with a history of high blood pressure, anxiety, urinary problems or cardiac disease are advised to consult a physician before taking Synephrine. In addition, combining Synephrine with other medicines with similar side effects could lead to dangerous complications.

Yohimbe (1.5 mg): This ingredient is a tree bark containing a variety of pharmacologically active chemicals. A number of studies support Yohimbe’s positive effect on weight loss, but its effects are not dramatic. Serious side effects associated with products containing Yohimbe have been reported to the FDA, including renal failure, seizures and death. The major alkaloid in Yohimbe is Yohimbine, a chemical that induces vasodilation, thereby lowering blood pressure. Additional side effects could include anxiety attacks. At high doses, Yohimbine acts as a monoamine oxidase (MAO) inhibitor. MAO inhibitors can cause serious adverse effects when taken in combination with tyramine-containing foods (e.g. liver, cheese and red wine) or with over-the-counter (OTC) products containing phenyl- propanolamine, such as nasal decongestants and diet products. Individuals taking Yohimbe are warned to avoid these foods and OTC products due to the increased risk of adverse effects. Yohimbe should also be avoided by individuals suffering from hypotension (low blood pressure), diabetes, and heart, liver or kidney disease. Symptoms of overdose include weakness and nervous stimulation followed by paralysis, fatigue, stomach disorders and ultimately death.

Tribulus terrestris (80% Saponins; 200 mg): This compound is known to boost testosterone levels, thus increasing muscle mass and enhancing libido. Tribulus has long been used to treat a variety of conditions such as low energy, depression, impotence, infertility in men and women and to boost vigor and strength. Tribulus is frequently used to promote fat loss. Little is known about the long-term use of Tribulus terrestris consumption in man. As with most herbs, it is best to take breaks from use in order to minimize potential long term tribulus side effects. Side effects reported by Tribulus terrestris users include feeling warmer, slight elevation in heart beat and restlessness. These tribulus terrestris side effects are dose dependent and are more common at doses above 500 mg.

TestoRipped conclusion

TestoRipped is not a regular diet pill and is not recommended for the average person looking to lose weight. Although TestoRipped does not contain ephedra it is a stimulant heavy diet pill. If sensitive to stimulants, this is a weight loss product that is best avoided. However, there are many positive testimonials from people that have lost weight and gained muscle using TestoRipped, particularly those following sensible diet and exercise routines.

Adipril Side Effects


The ingredients in Adipril can also be found in another diet pill, LipoFuze. In weight loss products the ingredients need to be present in potent enough dosages to have any effect. As the amount of each ingredient in Adipril is not disclosed, it is difficult to assess if they present in high enough dosages to promote significant weight loss. The effects of potential interaction between the 14 ingredients in Adipril have not been clinically evaluated. Internet sites have reported that some users have experienced profuse sweating, headaches, nausea, insomnia and increased heart rate after taking Adipril.

Related article: Adipril Review

Adipril ingredients

The fat burner Adipril contains 6 patented and 4 clinically tested ingredients. The ingredients include:

Bioperine: This ingredient is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). Bioperine contains 95 percent piperine and has been demostrated in clinical studies to increase the absorption of ingredients in nutritional supplement formulations. Additional absorption may not necessarily be beneficial. It is possible that the use of Bioperine may increase the side effects of certain supplements or drugs due to increased absorption.

ForsLean: ForsLean is derived from the root of Coleaus forskohlii. It is the only known plant source of the natural compound Forskolin. This compound is believed to increase lean body mass and help optimize body composition though cAMP (cyclic adenosine monophosphate) activation. A number (but not all) of clinical studies have indicated that taking Coleaus forskohlii may result in an increase in heart rate and a decrease in blood pressure.

FucoPure: This is a seaweed extract and is the patented version of fucoxanthin. There are a number of studies that indicated that fucoxanthin has the ability to boost metabolism, but to date, they all of these studies have been carried out on animals. It has also been shown that fucoxanthin cannot be easily absorbed by the human body. Additionally, it has been demonstrated clinically that compounds such as fucoxanthin have low bioavailability in man (e.g. Br J Nutr. 2008;100(2):273-7). One gram of seaweed has several times the amount of iodine that most adults require on a daily basis. Therefore, a potential fucoxanthin side effect could include changes in thyroid function due to iodine excess.

Green tea: Green tea has been shown to promote modest weight loss. However, it needs to be taken in relatively high concentration, and to contain high levels of catechins. In Adipril, the amount of green tea present in the formulation is not indicated. Users of green tea sensitive to caffeine could experience any of the following side effects: irritability, restlessness, nausea, insomnia, tremors, heart palpitations, upset stomach, frequent urination and skin rash.

GuggulEZ100: This ingredient is a patented extract of Commiphora mukul. Other common names for GuggulEZ100 are Gugalipids and Guggul. In India Guggul is used to treat high blood cholesterol. It lowers cholesterol and triglyceride levels and helps maintain a healthy balance of HDL, the good cholesterol, relative to LDL, the bad cholesterol (the HDL/LDL ratio), thereby protecting against cardiovascular disease and atherosclerosis. Studies have concluded that Guggal is safe and effective in lowering the various lipid fractions that are known to contribute to coronary heart disease. There is some clinical evidence to suggest that Guggul may promote fat burning (e.g. J Postgrad Med. 1995;41(1):5-7) by stimulating the secretion of the thyroid T3 hormone.

Razberi-K: This ingredient, also known as raspberry ketone or 4-(4-hydroxyphenyl) butan-2-one, is believed to promote weight loss by stimulating norepinephrine. Razberi-K is claimed to aid fat oxidation, but clinical studies have not convincingly demonstrated its effectiveness. One study undertaken on rodents showed that raspberry ketones blocked fat synthesis as well as an increase in blood triglycerides and helped to prevent excess weight gain. The chemical structure of raspberry ketone is similar to that of capsaicin and synephrine. Both of these compounds have the ability to boost thermogenesis through the release of norepinephrine. However, there are health risks associated with the use of these two ingredients; synephrine has been demonstrated to have cardiovascular side effects, while capsaicin has been shown to cause gastrointestinal problems in many users. No side effects related to raspberry ketone consumption have been reported.

Synephrine HCL: Synephrine is derived from the Citrus aurantium plant used in traditional Chinese medicine. Synephrine can help burn fat, suppress appetite and increase energy. However, clinical studies have revealed that Citrus aurantium induces only a relatively modest increase in thermogenesis. Reported side effects include headache, anxiety, insomnia, nervousness, tremor, dry mouth, blurred vision, increased heart rate and blood pressure. Synephrine may also reduce the ability to urinate. Consult a medical practitioner if you have any history of high blood pressure, anxiety, urinary problems or cardiac disease. In addition, combining decongestants with other medicines with similar side effects may lead to dangerous complications.

ThermoDiamine: This ingredient is the patented version of evodiamine, a Chinese fruit that is claimed to burn body fat by increasing the production of heat and reducing the ability to store fat. However, no studies have been conducted in man so far. At present only an animal-based study has been carried out and there is no clinical data on whether or not evodiamine is an effective weight loss agent in human subjects.

Capsaicin: This compound is extracted from Chile peppers. It is thought that capsaicin generates heat in the body thereby boosting the burning of calories. However, it appears that very high doses are required for capsaicin to be effective. Severe gastrointestinal side effects have been reported in patients taking capsaicin. While rare, serious allergic reactions to capsaicin can occur. Contact a doctor immediately should difficulty breathing, swelling of the throat, lips, or face, severe dizziness, skin rash, hives or itching be experienced.

7-OXO DHEA: This ingredient is a metabolite of the steroid hormone DHEA. This metabolite has been demonstrated to have a positive effect on thyroid hormone levels in obese subjects, without apparent side effects (e.g. J Nutr Biochem. 2007; 18(9):629-34. Current Therapeutics. (7):435-442 2000). 7-OXO DHEA has been found to be safe in animals at high doses and in humans at up to 200 mg daily. 7-OXO-DHEA should not be taken if you are being treated with glucocorticoids, because it may interfere with their effectiveness.

Is Adipril effective?

User feedback on Adipril has varied. Some slimmers have reported rapid weight loss in the first few days (water loss?) when combined with diet and exercise, but the rate of weight loss is lower than claimed by the manufacturers.

BetaStax Side Effects


BetaStax is a diet pill designed to burn fat, preserve lean muscle and provide energy. It is one of the most popular fat burner products sold at major online retailer BodyBuilding.com and can also be purchased in stores. Some consumers have complained of side effects including stomach discomfort, constipation, nervousness, jitters, dizziness and lightheadedness.

See also: BetaStax review

BetaStax pros

  • BetaStax can be purchased in stores including GNC
  • There are some testimonials presented on the website
  • BetaStax does have a return guarantee but only on unopened bottles

BetaStax cons

  • There is a large number of ingredients in this supplement
  • Caffeine is one of the key ingredients and can have side effects
  • At the time of writing clinical trial results are not detailed by the manufacturer

Side effects of BetaStax

Users frequently report a surge of energy after taking BetaStax. The manufacturer suggests starting with half the dosage to assess tolerance. Some consumers have complained of side effects including nervousness, jitters, dizziness, stomach discomfort, constipation and lightheadedness. Ingredients in BetaStax that could cause side effects include:

Caffeine: This compound is incorporated into many weight loss supplements available today. There are numerous warnings from the manufacturer in relation to BetaStax. The majority are targeted at pregnant and nursing women, probably due to the caffeine content of the supplement. Caffeine can cause anxiety, headaches, diarrhea, insomnia and increased heart rate. BetaStax does contain other stimulants such as Citrus aurantium that can cause jitters and other caffeine-type side effects.

Chromium: Chromium has reported side effects, even when taken in low doses of 200-400 mcg per day. These side effects include headaches, insomnia and sleep disturbances. Irritability, mood change and some weight gain may also occur. There have been cognitive, perceptual and motor dysfunction reported in some extreme cases. A high dose of chromium, 600-2400 mcg per day, may cause anemia, thrombocytopenia, hemolysis, hepatic dysfunction and renal failure.

Advantra-Z: This compound is a patented form of Synephrine, an alkaloid that is derived from Citrus aurantium. It is considered as a safe alternative to the now banned Ephedra and is believed to promote thermogenesis. Manufacturers claim that Synephrine provides the fat burning effects of Ephedra, but without side effects such as sleeplessness, jitters, elevated blood pressure, etc. However, there are studies that indicate that Synephrine can elevate blood pressure and heart rate (e.g. Ann. Pharmacother. [2006] 40(1):53-7).

CLA: Clinical studies have demonstrated that there are no adverse side effects associated with CLA when taken at the recommended dose. However, some users have reported stomach upset, stomach ache and in some cases mild diarrhea. Some individuals have reported feeling slightly nauseous after taking CLA and there have been isolated cases of gastrointestinal upset or loose stools.

BetaStax safety

Betastax should not be used by individuals with medical conditions that include:

  • Pre-existing medical conditions or a family history of medical conditions such as heart, liver or kidney disease
  • Caffeine sensitivity
  • High blood pressure
  • Liver conditions
  • Conditions requiring treatment with an MAO Inhibitor
  • Glaucoma

BetaStax dosage

It is recommended that BetaStax be taken twice daily with morning and afternoon meals. A full daily serving is 4 capsules of BetaStax. Each bottle of BetaStax contains a 1 month supply (120 capsules in a single container). The manufacturer recommends taking 2 capsules prior to breakfast and 2 capsules prior to lunch with 8 ounces of water. Do not take in the evening. Do not exceed 4 capsules per day. Begin use with one-half the suggested serving for the first week (one capsule twice per day). For best results use as part of a sensible diet and exercise program. Consult a medical doctor prior to beginning any diet or exercise program.

BetaStax ingredients

Vitamin B1
Chromemate® (chromium polynicotinate)
Xanthicore™ Proprietary Blend:
Incorporated in each capsule is 768 mg of a proprietary blend that contains the following ingredients:

  • CLA (conjugated linoleic acid)
  • Caffeine
  • Advantra Z® (synephrine, Citrus aurantium)
  • Vinpocetine

PureWaySlim® Proprietary Blend: This blend contains a 250 mg combination of the following ingredients; CLA oil (providing 80% Conjugated Linoleic Acid), caffeine anhydrous, Advantra Z® Citrus aurantium fruit extract [standardized for synephrine], vinpocetine. , vegetable wax extract (standardized for 10% fatty acids), fenugreek extract (Trigonella foenum graceum) (seed) (standardized for 5% galactomannan), Astragalus root extract (Astragalus membranaceus L standardized for 5% polysaccharides), Tribulus terrestris fruit extract standardized for 5% saponins, Magnolia bark extract (Magnolia officinalis standardized for 1% honokiol), French lilac extract (Syringa vulgaris standardized for 5% saponins), Jojoba fruit extract (Simmondsia chinensis standardized for 1% phenolics), Phellodendron amurense leaf and stem extract standardized for 1% berberine), Eurycoma longifolia whole plant extract standardized for 1% saponins), and rice bran extract standardized for sterols, polyphenols, amino acids, polysaccharides, vitamins and fatty acids).

Other ingredients: Gelatin, rice bran oil, d-alpha tocopheryl acetate, titanium dioxide.
Allergen information: Contains corn, rice, animal products (beef, pork).

Curvelle Side Effects


Some users of Curvelle have reported side effects that include upset stomach and jitteriness. Diet pills may contain ingredients that interact with other medications. If taking prescription drug or herbal medications, consult a medical professional for advice before taking Curvelle. Weight loss pills such as Curvelle are not FDA-approved for weight loss. Curvelle contains caffeine. Since caffeine is a stimulant, do not take Curvelle within 4 hours of sleeping. If taking Curvelle, reduce caffeine intake from other sources. Too much caffeine can cause nervousness, jittery feelings and heart palpitations.

What is Curvelle?

Curvelle is a fat burner designed specifically for women. Curvelle claims to control sugar cravings, burn excess calories and contain antioxidants to enhance health and radiance. Although the manufacturer claims that Curvelle is an effective fat burner and appetite suppressant, the ingredients do not appear particularly potent.

See also: Curvelle Fat Burner for Women

Curvelle ingredients

Curvelle contains a proprietary blend of 683 mg of ingredients that include:

Cinnulin PF: An extract from cinnamon bark that is believed to be able to balance the sugar levels in the bloodstream. Stabilization of insulin function is of great importance to slimmers. It is rapidly fluctuating blood sugar levels and the subsequent craving for sweet foods that hampers the efforts of many dieters. High doses of cinnamon have actually been demonstrated to be toxic, but Cinnulin PF has been tested clinically and shown to be safe to ingest daily.

Green tea: Contains caffeine that speeds up the body’s metabolic rate. The combination of green tea (standardized for caffeine and ECGC) and caffeine has been demonstrated to promote weight loss (Obes Res. 2005; 13: 1195-204). Users sensitive to caffeine could experience any of the following side effects: restlessness, irritability, sleeping problems, tremors, heart palpitations, loss of appetite, upset stomach, nausea, frequent urination and skin rash.

Razberi K: This compound is a ketone found in red raspberries. It is believed to help reduce body fat by decreasing dietary fat absorption in the small intestine, and stimulate increased production of the neurotransmitter norepinephrine which promotes the breakdown of fat stored in cells. There are no reported side effects in taking Razberi K.

Slow release natural caffeine: This variant of caffeine is incorporated in Curvelle. As good as this may be, dieters who are especially sensitive to caffeine should be careful when considering using Curvelle. This diet pill contains caffeine at a dosage equivalent to 3 cups of coffee. Excess caffeine may cause jitters, insomnia, headaches, increased heart rate and blood pressure.

Elderberry extract: This extract is rich in anthocyanins and antioxidants which have been shown to improve health and help fight oxidative stress in the body. There are no recognized adverse effects, although data is limited. It is suggested that a diuretic of elderberry extract may result in hypokalemia, but this has not been scientifically studied. There are no recognized drug interactions in taking elderberry extract. The stems, roots, unripe berries, and seeds may contain cyanide, and could cause vomiting and severe diarrhea if chewed or eaten uncooked. Ripe berries are safe when prepared for use in foods.

Curvelle dosage

Each container of Curvelle contains 100 capsules. Isotori, the manufacturers of this product, suggest taking two capsules before breakfast and lunch, as well as two before exercise.

Size 0 Side Effects


There are several stimulants in the weight loss formula of the Fat Burner by Size 0 Labs. The caffeine, green coffee bean, green tea and Cha de Bugre all include stimulants that have been reported to cause jitters, headaches, nausea, stomach problems and other health issues in some users.

See also: Size 0 Fat Burner Review

Size 0 ingredients

The relevant weight loss ingredients in Size 0 are as follows:

Caffeine anhydrous: This compound is a thermogenic agent with clinically proven benefits for weight loss. Caffeine may cause jitters, insomnia, headaches, increased heart rate and raised blood pressure.

Green tea extract: There is evidence to indicate that green tea offers benefits to dieters. Studies have shown that the tea can elevate metabolism and inhibit the action of the enzyme amalyse. Users sensitive to caffeine could experience any of the following side effects: restlessness, irritability, sleeping problems, tremors, heart palpitations, loss of appetite, upset stomach, nausea, frequent urination and skin rash.

Green Coffee Bean Extract: Coffee made from green, unroasted coffee beans has recently been found to promote weight loss. The discovery parallels earlier research on green tea. Green coffee appears to have a more potent effect. There are two key types of compounds in unroasted coffee beans. The first is caffeine and the second is chlorogenic acid and its related compounds. Heating destroys the acids. Currently, there are no clinical studies on green coffee extract’s weight loss effects on humans. In human trials, no significant adverse effects have been seen. In theory, the caffeine content of green coffee bean extract could potentially cause problems for some people. However, since the compound only contains about 10% caffeine by weight, a high daily dose contains no more than about 20% of the caffeine content of a strong cup of coffee. Maximum safe doses in pregnant or nursing women, young children, or people with liver or kidney disease have not yet been established.

Naringin Citrus Extract: A powerful bioflavanoid found in grapefruit, giving it its bitter flavor. Naringin works synergistically with other nutrients, increasing their bio-availability and extending their effects in the body. This citrus extract also interferes with enzyme activity in the intestines, and therefore can inhibit the breakdown of certain drugs. Naringin has been shown to be non-toxic at levels many times greater than the recommended dosages. Even when taken daily, naringin seldom produces a significant allergic reaction. However, people who are allergic to citrus fruits should exercise caution in the use of naringin.

Cordia Salisifolia Extract: This extract, also known as Cha de Bugre, is becoming a common ingredient in weight loss products and supplements. While no significant side effects have been reported Cha de Bugre does contain caffeine.

Also present is cocoa extract, probably included as a mood enhancer.

In addition to the thermogenic complex in Size 0, there are three additional complexes:

Appetite Support Complex: A blend of Hoodia gordonii, jojoba seed extract and Griffonia simplicifolia seed extract.

Beauty Support Blend: A blend of biotin, collagen, choline, horsetail leaf extract, hyaluronic acid, inositol, l-cycsteine, l-methionine, coenzyme Q10, silica, and chamomile flower leaf extract.

Estrogen Support Complex: A blend of chaste tree berry, daidzen, dong quai root and vitex agnus castus.

Size 0 recommended dosage

Each bottle of Size 0 contains 100 tablets As a dietary supplement, the manufacturers recommend taking 1-2 tablets, 2-3 times daily, 30 minutes before eating, with 16 oz of water. Begin use with a lower dose to assess tolerance.

Side-Effects of Clenbuterol


More and more women are using Clenbuterol, which is commonly called “Clen”, to lose weight quickly. Fore some, this could be a potentially life threatening decision. Even short-term usage of Clenbuterol is known to produce side-effects such as headaches, muscle tremors, insomnia, restlessness, palpitations, increased perspiration, muscle spasms, increased blood pressure, and nausea. Long-term consumption of Clenbuterol may lead to serious health problems. Permanent side effects, such as left-sided cardiac atrophy, can occur very quickly; in as little as one month in some cases when Clenbuterol is taken in high doses.

See also related article: Clenbuterol and Weight Loss

What is Clenbuterol?

Recently, the media have been reporting on the revelation that, for well over a decade, celebrities have been using Clenbuterol. Clenbuterol HCL, also known as Clenbuterol Hydrochloride, Ventipulmin, Spiropent, Novegam and Oxyflux, is a drug that is growing in popularity as an illegal diet pill.

Clenbuterol was initially developed to alleviate asthma symptoms in horses by relaxing the muscles in the airways. Its stimulant effect on the heart and central nervous system is comparable with adrenalin or amphetamines.

Clenbuterol is illegal in the US for human use. This is due to the fact that the drug has side-effects, such as palpitations and arrhythmia [irregular heartbeat], and has been linked to several cases of poisoning. In the US and most countries in Europe, Clenbuterol is prohibited for use in animals that will enter the food chain.

Although many dieters would like to use Clenbuterol for weight loss indefinitely, the drug is rarely taken for more than a month at a time. This is due to progressive loss of effectiveness. It is believed that this reduction in efficacy is due to a drug induced decline in the number of beta-2 receptors in the body over time, making Clenbuterol less potent. If the dose is increased, little additional benefit is achieved and side-effects become a major problem.

Side-effects of Clenbuterol

Clenbuterol is usually only effective for around 4 weeks. Thereafter, the body develops resistance to the drug. Short-term usage of Clenbuterol is known to produce side-effects. These side-effects are usually short-lived and often subside after 8-10 days, despite continued use of the drug. Side-effects of Clenbuterol are dose-dependant and include:

• Headaches
• Light-headiness
• Dizziness
• Pallor
• Heartburn
• Weakness
• Paradoxical bronchospasm
• Dysuria
• Dry mouth
• Muscular tremors (especially hand shakes)
• Muscular cramps
• Nervousness
• Insomnia
• Facial flushing
• Sweating
• Increased appetite
• Nausea and vomiting
• Chest pain
• Palpitations
• Tachycardia
• Hypertension (high blood pressure)
• Possible cardiac hypertrophy
• Heart muscle necrosis has been demonstrated in animal studies

After ingestion, Clenbuterol remains in the body for up to 39 hours. As a result of its long residence time, the adverse effects of Clenbuterol can be prolonged. Long-term consumption of Clenbuterol may lead to serious health problems. Permanent side effects, such as left-sided cardiac atrophy, can occur very quickly; in as little as one month in some cases when Clenbuterol is taken in high doses.

Clenbuterol overdose

Other side-effects can develop rapidly when overdosing on the drug: sudden racing heart beat (tachycardia), irregular heart beat (arrhythmia), depleted phosphate levels, potassium depletion, taurine depletion, headaches, tremors, vertigo and even stroke. Liver damage is also possible. Sudden death is possible at very high doses of Clenbuterol.

Symptoms may begin within minutes of ingestion of Clenbuterol at high doses, and last for hours/ days leading to prolonged toxicity due to the long-half life of the drug.

Because Clenbuterol can increase muscle definition and reduces fat, livestock are often dosed with the drug. In Spain in 1994, 140 people were hospitalised after they consumed meat tainted with Clenbuterol. They suffered dizziness, heart palpitations, breathing difficulties, shakes and headaches. In China recently, the newspaper People’s Daily reported that 336 people in Shanghai had been poisoned after eating pork contaminated with Clenbuterol. The drug had been banned by the Chinese government in the 1990s.

Clenbuterol interaction with other drugs

Caution is advised when using Clenbuterol in combination with other adrenoceptor agonists, as side effects are likely to be cumulative. It is for this reason that it is not recommended to use ephedrine/ephedra (or ma huang) or the ECA stack (ephedrine-caffeine-aspirin) whilst taking Clenbuterol.

Clenbuterol studies in rats

Researchers at the University of Melbourne in Australia recently gave Clenbuterol to laboratory rats at a dose of 2 milligrams per kilogram of body weight per day.
After only 4 weeks, Clenbuterol-treated rats were unable to maintain the activity levels of normal untreated rats. The hearts of the Clenbuterol-treated rats increased dramatically in size compared to untreated rats, but unfortunately heart growth was probably due to the infiltration of collagen fibres into the heart walls, not to an increase in heart-muscle cell size and density. Collagen is a tough connective tissue which stiffens the organs in which it grows. In the case of the heart, the presence of collagen fibers would lead to a decrease in cardiac output. Increases in collagen may also result in cardiac arrhythmias. Clenbuterol treated rats also suffered from noticeable cardiac-cell degeneration.

Clenbuterol and Weight Gain

Despite the fact that the list of potential side-effects induced by Clenbuterol is extensive, there is one side-effect that is probably of key interest to slimmers. In the long-term Clenbuterol is known to suddenly lose its efficacy and can cause rapid weight gain – possibly due to a sudden slowing in the body’s metabolic rate.

Clenbuterol dosage

Clenbuterol can be administered as an inhaler spray, orally and intravenously. It is usually taken orally by slimmers and bodybuilders in dosages ranging between 20 and 60 micrograms a day. Users who have never taken Clenbuterol before, or users who have been off the drug for several weeks or months, typically start with one 20 milligram pill. Starting Clenbuterol at higher doses may induce noticeable side-effects.

Generally, Clenbuterol is gradually increased, depending on how well it is tolerated. The highest typical daily dose range is two to four tablets (40-80 micrograms) for women and two to eight tablets (40-160 micrograms) for men.

The information presented in this article is strictly for educational purposes only and is not intended to replace the advice or attention of healthcare professionals.

Side Effects of Hot Rox Extreme


Reported side effects from taking Hot Rox Extreme weight loss pills include the jitters, rash, headaches, insomnia, hot flashes, severe nausea and dizziness. The manufacturer recommends that that pregnant or breast feeding women should not take Hot Rox Extreme. Those who are elderly or chronically ill should also avoid Hot Rox Extreme. Due to the presence of piperine in Hot Rox Extreme, patients taking medications should avoid this supplement.

The Food and Drug Administration have not evaluated or issued statements on many of the ingredients in Hot Rox Extreme, and clinical studies have not been carried out on the product itself or potential interactions with prescription drugs. It is therefore not advisable to take Hot Rox Extreme without consulting a medical practitioner.

How does Hot Rox Extreme work?

Hot Rox Extreme by Biotest is claimed to increase fat loss by up to 500%. It is said to achieve this by using a proprietary thermogenic formula which consists mainly of substances that increase lipase activity. Biotest heavily promote the apparent, ‘feel good’ effect after taking Hot Rox Extreme. This weight loss product is one of the latest generation of ephedra-free fat burners.

Hot Rox Extreme Dosage

Each bottle of Hot Rox Extreme contains 110 capsules. It is recommended to take 1 or 2 capsules of Hot Rox Extreme in the morning prior to breakfast and 1 or 2 capsules six hours later, each time on an empty stomach with 8 oz. of water. If a first time user of Hot Rox Extreme supplement, then begin by taking 1 capsule twice per day for 3 days prior to increasing the dose. Do not exceed 4 capsules in any 24-hour period. For best results, the manufacturer recommends taking Hot Rox Extreme for at least 1 month. If you have trouble sleeping, do not take Hot Rox Extreme within 6 hours of bedtime.

Ingredients of Hot Rox Extreme

There are two main active ingredients in Hot Rox Extreme: A7-E Super-Thermogenic Gel XXX500 and sclaremax, with guggulsterone functioning as a ‘booster’. Other ingredients include Carbolin™ 19, piperine, Yohimbine HCl, and caffeine.

A7-E Super-Thermogenic Gel: The website claims that A7-E is the longest lasting fat burning ingredient known to science. Biotest states that they have tested A7-E on human subjects, yet no clinical trial findings have been published.

Carbolin™ 19 (forskolin 1,9-carbonate): This is one of the ingredients incorporated in A7-E. Biotest claims that Carbolin 19 is a highly pure version of forskolin, which can help the body gain muscle mass. Unfortunately, the amount of forskolin in Carbolin 19, is not revealed.

Piperine: This compound is the alkaloid that makes black pepper so pungent. If any of the ingredients in Hot Rox Extreme Pills work the way that Biotest claims, then the addition of piperine could be helpful. Unfortunately, this compound could inhibit the metabolism of other drugs. In doing so, it may increase the bioavailability of other compounds, so a physician should be consulted prior to taking this weight loss supplement.

Yohimbine HCl: Biotest claims that Yohimbine HCl can block receptors that can make stubborn areas of the body resistant to fat loss. They present Yohimbine HCl as a fat spot reducer. A study conducted by the Institute of Sport Medicine, Sports Academy Belgrade did in fact find that Yohimbine HCl can reduce body fat in athletes. Yohimbine HCL may have excellent antioxidant potential. It is also believed to function as a vasodilator, boosting blood flow to the body’s extremities. As such, it has traditionally been used to treat erectile dysfunction. Do not use this ingredient is you have any form of hypertension.

Caffeine: The amount of caffeine in Hot Rox Extreme is not given. This is a cause for concern. Caffeine is a thermogenic compound. It has been shown to increase adrenaline levels; this hormone increases alertness and boosts energy levels. If sensitive to caffeine, potential side-effects can include: restlessness, irritability, sleeping problems, tremor, heart palpitations, upset stomach, nausea, frequent urination and skin rash.

Guggulsterones: Derived from the Indian Guggul tree, these compounds stimulate the thyroid gland to produce more thyroxin. This has the effect of increasing the body’s metabolic rate and, as a consequence, more fat is burnt. Some users have experienced gastrointestinal discomfort in taking guggulsterones.

Sclaremax: This compound is a diterpenoidal lactone found in a plant called Salvia sclarea. It is known to be an extremely potent adenylate cyclase activator, very similar to that of the diterpene derivative, forskolin, but with a much longer active life. The end result in taking this compound is stimulation of increased thyroid hormone production.

N-Acetyl-L-tyrosine: This is the amino acid tyrosine in free (unbound) form. Tyrosine is an amino acid that plays an important role in metabolism. It is the precursor to stimulatory neurotransmitters such as epinephrine, norepinephrine, dopamine and some of the thyroid hormones. All of these neurotransmitters and hormones play important roles in maintaining the body’s metabolic rate. Increased levels of tyrosine in the body can increase meatabolic rate. Several studies have also shown that tyrosine increases the benefits of caffeine/ephedrine products, in part by curbing appetite. The amount of L-tyrosine in Hot-Rox is not indicated on the product label. Toxicological studies indicate that tyrosine is quite safe.

Raspberry ketone: This is an aromatic compound found in red raspberries. Raspberry ketone has been shown to stimulate lipolysis in both white and brown adipose tissue.

The Hot Rox Extreme website

The Hot Rox Extreme website (Biotest.net) is a typical bodybuilding supplement website. It does, however, provide an ingredients label and a brief description of the product and some of its ingredients.

Hot Rox Extreme Pros

• Ephedra-free

Hot Rox Extreme Cons

• Contains caffeine
• Unsubstantiated claims
• On the expensive side
• Numerous negative customer testimonials
• There is not a 100% money-back guarantee with this product
• Propriety blend (ingredient amounts are not given)

Hot Rox Extreme Conclusions

Hot Rox Extreme is designed primarily for the bodybuilding community, and as such, should be avoided by the average person seeking to lose weight. Hot Rox Extreme has not yet been validated for safe use in man. There are no published clinical studies on this product.

Other Common Names: Biotest Hot Rox, Hot Rox Thermogenix, HotRox

Fenterdren Side Effects

Fenterdren is a fat burning diet pill that contains the stimulants synephrine, phenylethyamine and dicaffeine malate. The chemical make-up of synephrine is similar to ephedra and has been linked to a number of negative side effects including headaches, dizziness, elevated blood pressure and increased heart rate. Additionally, when added to other caffeine sources within the same product, it can further amplify these negative side effects. The makers of Fenterdren warn that users should not exceed the recommend dosage.

Another area of concern with Fenterdren is its combination of synephrine, phenylethylamine and dicaffeine malate. Research has shown that when these stimulating ingredients are combined, it can lead to adverse side-effects. These include anxiety, nervousness, insomnia, increased blood pressure, heart tremors and palpitations.

Fenterdren dosage

One bottle of Fenterdren 90 capsules and provides a one and a half month supply. The manufacturer recommends taking one capsule of Fenterdren with a full glass of water approximately thirty minutes before breakfast and one capsule with a full glass of water approximately thirty minutes before lunch. An intake of two capsules should not be exceeded in a 24 hour period.

Fenterdren ingredients

The ingredients in Fenterdren are synephrine (37.5 mg), phenylethyamine (37.5 mg) and dicaffeine malate (375 mg).

Dicaffeine malate: The compound may cause jitters, insomnia, headaches, increased heart rate and blood pressure. With 375 mg of caffeine, or the equivalent of nearly 4 cups of coffee, per capsule the effects of taking Fenterdren will certainly be felt. Originally used by the Coca Cola Company as an alternative to cocaine, DiCaffeine Malate is a stimulant-based ingredient used in soft drinks, energy drinks and dietary supplements. It combines natural caffeine with malic acid. The combination forms an ionic bonded compound which is gentle on the stomach and is claimed to optimize energy, stimulate thermogenesis and increase mental focus.

Synephrine: Since synephrine acts as a stimulant it is not recommended for individuals who are sensitive to caffeine, and those who have history of heart problems, high blood pressure and thyroid problems. Side effects of synephrine may include: rapid increases in blood pressure, cardiac arrhythmias, respiratory problems, dizziness, headaches, tremors, low blood sugar, blood sugar imbalances, flushing of the skin, restlessness and agitation, These side effects are all similar in scope to ephedrine and ephedra-based diet drugs that are now banned from the market.

At first, synephrine looked like it might be an alternative to ephedra. However, since that time, clinical research has shown that synephrine demonstrates relatively minor weight loss effects. Synephrine is a drug that releases adrenaline and noradrenalin the body in order to stimulate the metabolism. The compound is derived from the fruit of Citrus aurantium, and is usually listed as Bitter Orange, Zhishi, and Sour Orange in ‘natural’ weight loss products.

Ongoing research and clinical trials will provide more information on the long-term effects of syneprhine, but until then, there is no conclusive evidence that the drug is safe. Almost all diet pills that contain synephrine have not been approved by the FDA.

Phenylethylamine (PEA): PEA should not to be taken with MAO (mono amine oxidase) inhibitor drugs. MAO inhibitors are a potent class of medications used to treat depression. If you are pregnant or breastfeeding or are being treated for depression or other neurological conditions you should consult your health care professional before using this product.

PEA is becoming a popular ingredient in weight loss supplements. This endogenous neuroamine is found in chocolate, certain algae and is produced in the brain from the amino acid D-Phenylalanine. It improves mood very rapidly and has been called the ‘Love Chemical’ because of its effect on beta endorphins, an opioid peptide responsible for pleasurable feelings. Due to it neuro-modulating actions it plays a key role in the feed/reward mechanisms of dietary behavior. In reality, phenylethylamine is metabolized by the enzyme monamine oxidase, and very little ingested PEA actually reaches the brain. However, if very high concentrations of PEA it can reach the brain in quantities sufficient to mimic amphtamine.