The manufacturer of Slim9 claims that it is an all-in-one diet pill. Slim9 contains ingredients, some of which contain caffeine. Slim9 may cause side effects in some users which may include headaches, dry mouth, indigestion, nausea, jitteriness, nervousness, irritability, insomnia, dizziness, anxiety and elevated heartbeat.

See also: Slim9 Review

Slim9 pros

• The official product website offers a money-back guarantee, but only on unopened bottles

Slim9 cons

• Slim9 is a propriety blend. Are there high enough doses of the active ingredients for optimal weight loss effectiveness?
• Slim9 contains caffeine
• Some users report experiencing side effects using Slim9
• No details of the country where Slim9 is made or product quality control and purity are given on the website

Slim9 side effects

Due to the fact that Slim9 includes caffeine, green tea and guarana in the ingredient profile, side effects can occur in some users. For example, insomnia is possible if Slim9 is taken too close to bedtime. In customer reviews there are some reports of side effects ranging from headaches, dry mouth, indigestion, nausea, jitteriness, nervousness, irritability, insomnia, dizziness, anxiety to elevated heartbeat.

The manufacturer recommends that users “Discontinue use if you experience any adverse reactions, pressure abnormalities, diabetes, or are taking any blood thinning medication, or natural health product with anticoagulant/anti-platelet, or are taking antihypertensive/antidepressants. It is recommended to consult your healthcare provider before beginning any nutritional program. Keep out of the reach of children.”

Slim9 ingredients

Acai: Acai berries contain powerful anti-oxidants that can boost the immune system and can help cleanse the colon. However, there are no clinical studies to support the weight loss claims made by the manufacturers of weight loss products containing the berry. While acai can be a useful component of a weight loss plan that includes a calorie-controlled diet, by itself it is just another fruit. When taken at recommended dosages, there are no reported side effects.

Caffeine: This compound is found in many weight loss supplements. It is a recognized fatburner with clinically proven modest benefits for weight loss (e.g. Am J Clin Nutr. 1989;49(1):44-50; Am J Clin Nutr. 1980;33(5):989-97), although there are indications that it offers greater benefits to leaner individuals (Am J Physiol. 1995;269(4 Pt 1):E671-678). Caffeine can cause headaches, diarrhea, anxiety, jitters, insomnia and increased heart rate.

Dandelion root/leaf: This plant is also included in the formulation for its diuretic properties. Dandelion is generally considered to be a relatively gentle herb without any serious side effects. However, some people have reported allergic reactions from merely touching dandelion but this is rare. Patients who are on pharmaceutical diuretics or drugs that have a diuretic action should not take supplements containing dandelion. In such cases, one of the possible side effects/interactions of dandelion is that it could lower the potency of the synthetic drug. Individuals on diabetes medications should also be aware that dandelion might increase the blood sugar lowering effects of those pharmaceutical drugs.

Cayenne: The active compound in cayenne pepper is capsicum. Capsicum contains capsaicinoids, which are the family of compounds that cause the intense heat experienced when eating chili peppers. Capsanicinoids help to promote thermogenesis, carbohydrate oxidation and stimulate fat oxidation. However, it appears that very high doses are required for capsaicin to be effective. Severe gastrointestinal side effects have been reported in patients taking capsaicin. While rare, serious allergic reactions to capsaicin can occur. Contact a doctor immediately should difficulty breathing, swelling of the throat, lips, or face, severe dizziness, skin rash, hives or itching be experienced.

Ginger: Ginger contains oleoresins that are rich in gingerols. These compounds have a variety of sedative effects. Ginger is traditionally used to calm the stomach and as a treatment for motion sickness. Since some individuals experience gastrointestinal upset with caffeine and other stimulatory chemicals, ginger should help to eliminate this occasional side effect. Side effects associated with ginger are rare, but if taken in excessive doses the herb may cause mild heartburn, diarrhea and irritation of the mouth.

Ginseng: Ginseng has traditionally been used as a restorative tonic to increase energy, stamina and well being. Researchers have found that ginseng may be effective in promoting weight loss and diabetes control. Side effects of Ginseng can include nausea, diarrhea, headaches, nose bleeds, high blood pressure, low blood pressure and breast pain. Ginseng may also lead to induction of mania in depressed patients who mix it with antidepressants.

Green tea: Green tea has been shown to promote modest weight loss. However, it needs to be taken in relatively high concentration, and to contain high levels of catechins. Users of green tea sensitive to caffeine could experience any of the following side effects: irritability, restlessness, nausea, insomnia, tremors, heart palpitations, upset stomach, frequent urination and skin rash.

Guarana: Guarana is a common ingredient in many popular stimulant-based weight loss pills. It is included primarily for its caffeine content (caffeine is a potent thermogenic agent) but it also has anti-oxidant and diuretic properties. Harvested in Brazil and Uraguay, this wild-growing climbing shrub has been used for centuries as a general health-tonic and recently as an energizing drink. Guarana may cause side effects, but many people have no, or minor, side effects. Side effects can include: anxiety; diarrhea; headache; increased urination; nausea; nervousness; shakiness; tremors; trouble sleeping; upset stomach; and vomiting.

Theobromine: Theobromine has an effect that is similar to caffeine, but slightly milder. It is commonly used in both traditional medicine to treat and prevent a wide range of illnesses and disorders, including high blood pressure and coughs. Theobromine has been shown in clinical studies to reduce food intake. It has an appetite-suppressing effect. Theobromine is the “feel-good” ingredient in chocolate, and it can therefore help with the emotional aspects of weight loss. Side effects caused by theobromine include anxiety, restlessness, tremors, insomnia, nausea and vomiting.

Slim9 dosage

The manufacturer recommends taking on 635 mg capsule with a meal once daily. There are 30 capsules per container.

Professional Strength Hydroxycut Shape is a caffeine heavy diet pill designed for women. Exposure to 810 mg of caffeine when taking the maximum recommended 6 capsules per day means that Hydroxycut Shape is not a diet pill for individuals sensitive to stimulants, or those who have an underlying health conditions such as heart disease and high blood pressure, or are taking prescription blood thinning drugs.

See also: Hydroxycut Shape Review

Hydroxycut Shape Pros

• Manufactured in the US
• Can be purchased online and in stores (notably GNC)
• Partially backed by clinical studies

Hydroxycut Shape Cons

• Hydroxycut Shape is a propriety blend
• The official product website has no testimonials
• Hydroxycut Shape is not supported with a money back guarantee
• Hydroxycut Shape contains stimulants and side effects have been reported

Hydroxycut Shape side effects

Exposure to 810 mg of caffeine when taking the maximum recommended 6 capsules per day means that Hydroxycut Shape is not a diet pill for individuals sensitive to stimulants, or those who have an underlying health conditions such as heart disease and high blood pressure or are taking prescription blood thinning drugs. The manufacturer recommends the following: Do not use if pregnant or nursing. Discontinue use and consult a medical doctor if you experience unusual symptoms. Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under six years of age. In case of accidental overdose, call a medical doctor or poison control immediately. Take a few hours before or after taking other medications. Consult a medical doctor before use if you have been treated for or diagnosed with, or have a family history of any medical condition, or if you are using any prescription or over-the-counter drug(s), including blood thinners. Caffeine sensitive individuals may experience the following symptoms including (but not limited to) restlessness, nervousness, tremors, headache, anxiety, palpitations, increased heart rate, or difficulty sleeping. Do not combine with other sources of caffeine. Consult a medical doctor before starting any diet or exercise program. Do not exceed recommended serving. Improper use of this product will not improve results and is not advised. Use only as directed. Not intended for use by persons under 18. Do not use if pregnant or nursing. Discontinue use and consult a medical doctor if you experience unusual symptoms.

Hydroxycut Shape ingredients

Two capsules of Hydroxycut Shape contain a propriety blend of 443 mg of ingredients. The ingredients are calcium, vitamin C, folic acid, iron, L-carnitine tartrate, caffeine anhydrous, guarana, yerba mate, Lady’s mantle extract, ma-chin extract, wild olive extract, wild mint extract, gamma-oryzanol, and L-ornithine HCL.

Looking at the most relevant ingredients in greater detail:

W8 Lean™ Complex: This is a blend of 4 ingredients, namely Alchemilla vulgaris extract, Olea europaea extract, Cuminum cyminum extract and Mentha longifolia extract. Two clinical studies have been carried out on the W8 Lean™ Complex, but no details of where or when the studies were carried out have been provided on the Hydroxycut Shape website. According to Muscle Tech/Iovate, the manufacturer of Hydroxycut Shape the clinical study subjects involved in the independent study lost an average of 21 pounds over a 12 week period. This equates to 1.75 pounds of weight loss per week, well within the bounds of what can be accomplished with proper diet and exercise, without the aid of a diet pill. A separate 8-week study funded by Iovate yielded similar results when test subjects taking the same weight-loss complex lost an average of 16.50 lbs. versus 1.73 lbs. by the placebo group. All groups followed a calorie-reduced diet. It was not indicated whether or not side effects occurred in any of the test subjects.

L-Carnitine Tartrate: This ingredient is an amino acid that is associated with energy production from fat stores in the body. It may help reduce symptoms of angina, diabetic neuropathy and memory impairment. However, there are conflicting clinical study findings as to whether or not L-carnitine has a direct effect on weight loss. Potential side effects of L-carnitine include stomach discomfort and insomnia.
Caffeine: According to the labeling, Hydroxycut Shape contains 270 mg of caffeine per serving, which means the consumption of an enormous 810 mg when taking 6 capsules per day. This compound is incorporated into many weight loss supplements available today. There are numerous warnings from the manufacturer in relation to Hydroxycut Shape. Many are targeted at pregnant and nursing women, probably due to the caffeine content of the supplement. Caffeine can cause anxiety, headaches, diarrhea, nausea, insomnia and increased heart rate.

Gamma-Oryzanol: A group of constituents derived from rice oil bran. Normally, it is included in supplements to lower cholesterol or raise testosterone and / or hGH (human growth hormone) levels. Clinical evidence supporting its use, however, is extremely scarce. Gamma oryzanol has been utilized for the treatment of conditions ranging from stomach upset to high cholesterol, as well as anxiety and menopause. In addition, gamma oryzanol is taken by athletes and weight trainers in the belief that it will increases performance and promote muscle growth. Many websites report that gamma oryzanol increases hormone levels (testosterone, anabolic, and growth) and in order to produce such benefits. However, there is no real evidence to support this. Maximum safe doses for pregnant or nursing women, children and the elderly have not been established yet. The same holds true for individuals suffering from liver or kidney damage.

Guarana: Guarana is a common ingredient in many popular stimulant-based weight loss pills. It is included primarily for its caffeine content (caffeine is a thermogenic agent) but it also has anti-oxidant and diuretic properties. Harvested in Brazil and Uraguay, this wild-growing climbing shrub has been used for centuries as a general health-tonic and recently as an energizing drink. Guarana may cause side effects but many people have no, or only minor side effects. Side effects can include anxiety, diarrhea, headache, increased urination, nausea, nervousness, shakiness, tremors, trouble sleeping, upset stomach and vomiting.

Lady’s Mantle: This ingredient has been used since medieval times as a medicinal herb. Lady’s mantle is used for treating stomach problems, diarrhea, excess water retention, muscle contractions and diabetes. Other uses include relieving painful menstruation and symptoms of menopause. There is not enough evidence from human studies to determine the effectiveness of lady’s mantle for any medicinal use. Lady’s mantle contains tannins, which may help to manage diarrhea, a probable reason for its inclusion in the Hydroxycut Shape formulation. Lady’s mantle should be avoided during pregnancy and lactation.

L-Ornithine HCl: L-ornithine is a non-essential amino acid that it is abundant in protein foods such as meat, fish, dairy and eggs. It can induce the release of growth hormone (HGH) in the body, which in turn help promote fat metabolism. There appears to be no link between L-ornithine and weight loss or HCG production. L-Ornithine can cause more frequent recurrences of herpes outbreaks. In addition, there is a link between psychotic episodes and an increased intake of L-Ornithine. This amino acid may also accentuate the adverse effects of diabetes. In addition, the use of L-Ornithine can cause increased gastrointestinal distress. When this amino acid stimulates increased production of HGH the side effects might include excessive facial bone growth and malformation, joint swelling and pituitary gland malfunction.

Ma-chin Extract (Cuminum cyminum): Cumin is used in treating inflammation, indigestion, flatulence and as an appetite suppressant. The oil may have photosensitizing effects. Cumin in high doses may also cause hypoglycemia.

Wild mint extract: This herb has been used to calm stomach upset and reduce inflammation. But it has not been shown to promote weight loss. No side effects have been reported to date.

Wild Olive Extract: This ingredient is rich in beneficial fatty acids and antioxidants. However, it has not been shown to promote weight loss. From all olive leaf extract appears to be a safe supplement that can effectively aid the body in improving immune function and fighting infection. However, it is not advisable to take olive leaf with antibiotics as they can be inactivated by this herb. Olive leaf should not be taken with Warfarin (Coumadin) because this drug can cause internal bleeding. Olive leaf naturally relaxes blood vessels and capillaries which could increase this bleeding.

Yerba Mate: This ingredient is sourced from a South American shrub that contains the xanthine alkaloids caffeine, theobromine and theophylline. Yerba mate contains about half the caffeine of coffee. Theobromine and theophylline are stimulants, although they have a less powerful effect on the central nervous system than caffeine. Yerba mate is also contains chlorogenic acid, a compound which may have some weight loss properties. Flushing, nausea, vomiting, irritability, nervousness, increased urination and headache may occur with Yerba mate. If any of these effects persist or worsen, contact your doctor promptly. Stronger but very infrequent side effects include stomach pain, yellowing eyes and skin, dark urine, fever, muscle twitching and unusually fast/slow/irregular heartbeat.

Hydroxycut Shape dosage

A bottle of Hydroxycut Shape contains 210 liquid capsules. Users are encouraged to begin taking Hydroxycut Shape at a rate of one capsule twice daily before a main meal, and work up to a dosage of two capsules three times daily at day 5 and beyond.

This article is for educational purposes only. Practical- weightloss does not provide medical advice, diagnosis or treatment.

Gaspari Nutrition’s Phenorex is a fat burning pill formulated for use in combination with exercise. Two strong stimulants, caffeine and Advantra Z, are included in the Phenorex formulation. Reported Phenorex side effects include headaches, dry mouth, facial flushing, indigestion, nausea, jitteriness, nervousness, anxiety, irritability, dizziness, insomnia and elevated heartbeat.

See also: Phenorex Review

Phenorex pros

• Manufactured to a high standard by an established company

Phenorex cons

• There are several strong stimulants in Phenorex which can cause side effects
• Phenorex is primarily designed for Gym enthusiasts and may be too strong for the average dieter

Phenorex ingredients

Phenorex contains the following ingredients:

Carnipure, Oxytropis Falcate Extract, Caffeine, Advantra Z Citrus Aurantium Extract, Paullinia Cupana Extract, 3,5 Diiodothyronine and 3,3 Diiodothyronine, Vitamin B6, Vitamin B12 and Selenium.

Looking at the ingredients in greater detail:

Carnipure (l-carnitine l-tartrate): Carnitine is critical for energy formation and an active metabolism. Carnitine transports the fatty acids from blood into cells for energy production. Various forms of carnitine are used in fat burners, despite contradictory study findings. Acetyl-L-carnitine appears to be safe in general. Clinical trials have included children, with no marked side effects. However, there is some evidence that its usage may cause mild symptoms. They include nausea, vomiting, diarrhea, skin rash, agitation, increased appetite and altered or unpleasant body odor. Individuals taking certain drugs should probably avoid carnitine. Some drugs reduce its effectiveness, while others can react with carnitine resulting in negative side effects. These drugs include Cisplatin (a chemotherapy agent), the HIV drugs Didanosine and Stavudine, and Paclitaxel or Taxol (cancer drugs). Carnitine may be contraindicated for patients on dialysis or patients with high blood lipids. Patients with diabetes, heart disease, vascular disease and complications of alcoholism, consult their doctors before taking carnitine.

Oxytropis falcata extract: Also known as “locoweed”, is a toxic Chinese plant that has been used in ancient Chinese medicine for centuries as an anti-inflammatory. According to the manufacturer, Oxytropis falcata is standardized for biogenic amines, although they do not reveal which ones or to what potency they are standardized. It is believed to have the ability to reduce pain and work as a natural alternative to aspirin. However, Oxytropis falcate extract does not actually promote weight loss.

Caffeine: This compound is incorporated into many weight loss supplements available today. Caffeine can cause anxiety, jitters, headaches, diarrhea, insomnia and increased heart rate.

Advantra-Z: Advantra-Z is a patented form of Synephrine, an alkaloid that is derived from Citrus aurantium. It is considered as a safe alternative to the now banned Ephedra and is believed to promote thermogenesis. Manufacturers claim that Synephrine provides the “fat burning” effects of Ephedra, but without side effects such as sleeplessness, jitters, elevated blood pressure, etc. There are studies, however, that indicate that Synephrine can elevate blood pressure and heart rate (e.g. Ann. Pharmacother. [2006] 40(1):53-7).

Paullinia cupana extract (standardized for purine content): Also known as guarana. Guarana is a common ingredient in many popular stimulant-based weight loss pills. It is included primarily for its caffeine content (caffeine is a thermogenic agent) but it also has anti-oxidant and diuretic properties. Guarana may cause side effects that can include: anxiety; diarrhea; headache; increased urination; nausea; nervousness; shakiness; tremors; trouble sleeping; upset stomach; and vomiting.

35′ Diiodothyronine and 33′ Diiodothyronine: These are metabolites of the T3 thyroid hormone. Theoretically, supplementation with thyroid hormone derivatives can raise the levels of the T3 hormone, increasing metabolic rate and calorie burn.

Phenorex dosage

1-3 capsules twice per day

Phen375 (Phentemine 375) is made up of a synthetic fat burning formula. However, Phen373 is a propriety blend. Are there high enough doses of the active ingredients for optimal weight loss effectiveness? Phen375 is a stimulant heavy pill and some users have reported side effects.

See also: Phen375 review

Phen375 pros

• Phen375 is manufactured in an FDA regulated lab in California
• Phen375 is a pharmacy grade diet pill
• Phen375 has a 45 day money-back guarantee
• The customer is supported with a meal by meal diet menu for 30 days

Phen375 cons

• Phen375 has not been evaluated in clinical trials
• Phen375 is a propriety blend
• Phen375 contains caffeine
• Some users report experiencing side effects using Phen375

Side effects of Phen375

Reported side effects of Phen375 are:

• stool inconsistency
• dizziness
• drowsiness
• increase blood pressure levels
• elevated heart rate
• insomnia

Individuals with serious health problems should consult a doctor before taking Phen375. Precluded diseases include diabetes, hypertension and other chronic medical conditions.

Phen375 ingredients

The manufacturer of Phen375 does reveal its ingredients, but not the amounts present in the formulation. The ingredients are:

1,3,7-Trimethylxanthine: This is the chemical name for caffeine, the most common ingredient in over the counter fat burners and weight loss products. This compound is found in many weight loss supplements because it is a recognized fatburner with clinically proven benefits for weight loss (e.g. Am J Clin Nutr. 1989;49(1):44-50; Am J Clin Nutr. 1980;33(5):989-97). Caffeine can cause headaches, diarrhea, anxiety, jitters, insomnia and increased heart rate.

1,3-Dimethylpentylamine hydrochloride: This ingredient is also known as Geranium extract, 1-3 Dimethylamlyamine and DMAA. It functions as a central nervous system (CNS) stimulant. Although originally developed as a nasal decongestant by Eli Lilly, methylhexaneamine has been marketed by certain companies as a dietary supplement in combination with caffeine and other ingredients, under trade names such as Geranamine and Floradrene, to be used as a thermogenic or general purpose stimulant. Methylhexaneamine itself has not been studied intensively and its pharmacological profile has not been evaluated. Its stimulant effects on the CNS are less pronounced than those of the related compounds amphetamine and ephedrine. Methylhexanamine has a structural similarity to amphetamine, and even greater similarity to propylhexedrine, which may account for its similar mode of action to these compounds. In New Zealand, methylhexanamine (under the name 1,3-dimethylamylamine or DMAA) is an emerging active ingredient of party pills. Side effects including headache, nausea and stroke have been reported in recreational users of these products.

Dehydroepiandrosterone: This compound is commonly called DHEA. In the promotion of weight loss, DHEA does not appear to be particularly effective. Few side effects have been reported when DHEA supplements have been taken orally at the recommended doses. Side effects may include fatigue, nasal congestion, headache, acne, or rapid/irregular heartbeats. In women, the most common side effects are abnormal menses, emotional changes, headache and insomnia. Individuals with a history of abnormal heart rhythms, blood clots or hypercoagulability, and those with a history of liver disease, should avoid DHEA supplements. As a hormone precursor, there have been a few reports indicating side effects possibly caused by the hormone metabolites of DHEA. Some of these side effects include possibly serious cardiovascular effects such as heart palpitations.

L-Carnitine: This is an ingredient commonly found in weight loss pills. Carnitine plays a key role at the cellular level in the metabolism of fatty acids to provide energy. Studies to date have not convincingly demonstrated that carnitine supplementation can significantly boost calorie burn. This is a naturally occurring nutrient that has been taken for hundreds of years and is likely safe for normal individuals. However, there may be certain side effects associated with L-carnitine such as upset stomach or nausea. Some sources report that a fishy odor in the urine, sweat and breath can occur, but that is probably only associated with a high dosage of the compound. Individuals with cancer or HIV should not take L-carnitine without prior medical advice. This is because L carnitine may interfere with the activity of medicines used in treating these diseases. L carnitine supplements have been known to increase the frequency and/or seriousness of seizures for people that have a history of them. It has been theorized that the reason for this may be because L carnitine promotes increased cellular activity and energy, which in turn may trigger the “switch” which causes a seizure episode. There is not sufficient information as to whether there are any L carnitine side effects for women who are pregnant. Therefore it is advisable to avoid L carnitine unless directed by a doctor. There is some research which suggests that L carnitine supplements might also possibly interfere with the secretion of the thyroid hormone thyroxin.

Capsiplex, manufactured by Advanced Health Limited, is claimed to be a diet pill used by celebrities. Capsiplex contains capsicum extract (chili pepper) with a small amount of caffeine, black pepper extract (piperine) and niacin. Side effects of capsicum, the principal active ingredient in Capsiplex, have been reported infrequently. These include upset stomach, heartburn, hot flushes and diarrhea. However, it is potentially unsafe to take capsicum in large doses or for long periods of time. In rare cases, this can lead to more serious side effects such as liver or kidney damage.

See also: Capsiplex Review

Capsiplex Pros

• Capsicum, the key ingredient in Capsiplex, has been shown to boost metabolism in clinical studies
• The Capsiplex website provides full contact details including the name and contact address of the manufacturer – Quite rare in the diet pill industry
• Capsiplex is featured in numerous newspapers and online news portals as an effective slimming product

Capsiplex Cons

• The manufacturer claims that Capsiplex can promote the burning of up to 278 extra calories. However, these are the total average calories burned before, during and after exercise. So without any exercise, it is open to question how effective Capsiplex really is
• Some users of Capsiplex may experience side effects

Capsiplex side effects

Side effects for capsicum, the principal active ingredient in Capsiplex, have been reported infrequently. These include upset stomach, heartburn, hot flushes and diarrhea. However, it is potentially unsafe to take capsicum by mouth in large doses or for long periods of time. In rare cases, this can lead to more serious side effects such as liver or kidney damage.

Allergies and Capsiplex
Do not take capsicum without first consulting a doctor if allergic to peppers (green, red, orange, yellow, chili, peppercorns, etc.) or capsicum. Also consult a doctor, pharmacist or health care professional before taking capsicum if you have other allergies (especially to plants), have any medical condition, or take other medicines or other herbal/health supplements. Stop taking capsicum and seek emergency medical attention if you experience symptoms of a serious allergic reaction including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives.

Pregnancy and Capsiplex
Do not take capsicum without first talking to a doctor if pregnant or breast-feeding. It is not known whether capsicum will be harmful to a nursing infant. There is no information available regarding the use of capsicum by children. Do not give any herbal/health supplement to a child without first talking to the child’s doctor.

Surgery and Capsiplex
Capsicum might increase bleeding during and after surgery. Stop using capsicum at least 2 weeks before scheduled surgery. Capsicum might slow blood clotting. Taking capsicum along with medications that also slow clotting might increase the chances of bruising and bleeding. Some of these medications include aspirin, warfarin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Theophylline interaction with Capsiplex
Theophylline is a drug used in therapy for respiratory diseases such as COPD or asthma. Capsicum can increase the absorption of theophylline by the body. Taking capsicum together with theophylline might increase the effects and side effects of theophylline.

Capsiplex interaction with blood pressure drugs
Some drugs for high blood pressure (ACE inhibitors) interact with capsicum, amplifying side effects such as coughing.

Capsiplex and drug absorption
Capsicum can affect the absorption rate of other herbs and prescription medications.

Capsicum and cancer
Some animal studies have shown that capsicum can induce liver tumors and adenocarcinomas in the intestine, although these effects have not been shown in humans.

Capsiplex ingredients

Red hot chilies or capsicum extract is the principal ingredient in Capsiplex while caffeine, black pepper extract (piperine) and niacin are also present. To minimize the side effects of concentrated red hot capsicum extract, the tablet has a specially designed coating.

Looking at the ingredients in greater detail:

Capsicum Fruit Extract: This compound is extracted from Chile peppers. Capsicum has not been evaluated by the FDA for safety, effectiveness or purity. Capsicum contains Capsaicinoids, which are the family of compounds that cause the intense heat experienced when consuming chili peppers. Capsanicinoids help to promote thermogenesis, carbohydrate oxidation and stimulate fat oxidation. It is thought that capsaicin generates heat in the body thereby boosting the burning of calories. However, it appears that very high doses are required for capsaicin to be effective. Capsicum is known to stimulate the appetite. Severe gastrointestinal side effects have been reported in patients taking capsaicin. While rare, serious allergic reactions to capsaicin can occur. Contact a doctor immediately should difficulty breathing, swelling of the throat, lips, or face, severe dizziness, skin rash, hives or itching be experienced.

Caffeine Anhydrous: This compound is found in many weight loss supplements because it is a recognized fatburner with clinically proven benefits for weight loss (e.g. Am J Clin Nutr. 1989;49(1):44-50; Am J Clin Nutr. 1980;33(5):989-97). Caffeine can cause headaches, diarrhea, anxiety, jitters, insomnia and increased heart rate.

Black Pepper Extract (Piperine): Piperine has been shown in clinical research to increase the absorption of ingredients in nutritional supplement formulations. Additional absorption, even if true, may or may not necessarily be beneficial. It is possible that the use of Piperine may increase the side effects of certain supplements due to increased absorption. It is possible that the use of Piperine may increase the side effects of certain supplements or drugs due to increased absorption. Minor gastrointestinal discomfort or GI symptoms may occur with high doses of Piperine.

Niacin: This B vitamin plays a major role in releasing energy from carbohydrates, proteins and fats. This is the why niacin is included in some weight loss supplement formulas. The most notable niacin side effect is flushing after intake of relatively large doses of niacin (75 mg or more). Flushing may occasionally be coupled with niacin itching and niacin rashes. Some of the niacin side effects reported after high doses (higher than the threshold amount) of the vitamin include gastrointestinal symptoms such as vomiting, nausea, flatulence, bloating and diarrhea as well as a decrease in blood pressure. Very rare side effects range from simple dryness and scaliness of the skin, excessive pigmentation, to liver disorder, blurred vision, activation of peptic ulcers and jaundice.

Capsiplex dosage

Capsiplex is taken once daily in the morning or for the best results 30-60 minutes before exercise. There are 30 capsules, or one months supply.

Clinical studies have not been carried out on the efficacy of Liporexall, or its potential side effects. However, studies have been carried out on the individual ingredients. Liporexall contains caffeine. In some people, stimulants like this can cause side effects such as restlessness, headaches, jitteriness, nervousness, irritability, insomnia, palpitations, elevated heartbeat and increased blood pressure.

See also: Liporexall Review

Liporexall side effects

Many diet pills have side effects that are usually caused by the incorporation of stimulant-based ingredients in their formulations. Individuals that are sensitive to caffeine are particularly susceptible to these side effects. Liporexall contains caffeine. In some people, stimulants like this can cause side effects such as restlessness, headaches, jitteriness, nervousness, irritability, insomnia, palpitations, elevated heartbeat and increased blood pressure. Side effects may also be experienced if allergic to any of the ingredients.

Liporexall pros

• Clinically evaluated ingredients
• The official product website offers a money-back guarantee

Liporexall cons

• Clinical studies have not been carried out on Liporexall itself
• Contact details for the manufacturer are limited to an email address. No telephone number or mailing address is given
• Numerous negative testimonials have been posted related to the efficacy of Liporexall
• Liporexall is a propriety blend. Are there high enough doses of the active ingredients for optimal weight loss effectiveness?
• No details of the manufacturer, the country where Liporexall is made, product quality control and purity are given on the website

Liporexall ingredients

Liporexall‘s ingredients are:

Super CitriMax has been shown clinically to reduce appetite, burn fat and lower blood cholesterol levels. The active ingredient, hydroxycitric acid (HCA) is derived from the rind of the Garcinia cambogia fruit. A review of 14 studies indicated that HCA and Super Citrimax caused no adverse side effects at doses of up to 2,800 mg daily [4,667 mg of Super Citrimax]. There are no known drug interactions associated with the use of HCA. However, patients taking oral hypoglycemic agents are advised to use caution before taking HCA, due to the possibility of amplifying the action of hypoglycemic medications. Consult a physician before commencing use. Individuals diagnosed with Diabetes mellitus should use extreme caution in taking HCA/Garcinia cambogia due to its glycemic action. People with Alzheimer’s disease or other dementia syndromes should also avoid using HCA.

Tonalin CLA is extracted from safflower oil. CLA (conjugated linoleic acid) suppresses the enzyme that promotes the storage of body fat. Tonalin CLA is the highest quality form of CLA available. Clinical studies have demonstrated that there are no adverse side effects associated with the use of Tonalin CLA when taken at the recommended dose. However, some users have reported stomach upset, stomach ache and in some cases mild diarrhea. Some people report feeling slightly nauseous after taking CLA, and there have been isolated cases of gastrointestinal upset or loose stools.

Advantra-Z is a patented form of Synephrine, an alkaloid that is derived from Citrus aurantium. It is believed to promote thermogenesis. Manufacturers claim that Synephrine provides the “fat burning” effects of Ephedra, but without side effects such as sleeplessness, jitters, elevated blood pressure, etc. There are studies, however, that indicate that Synephrine can elevate blood pressure and heart rate (e.g. Ann. Pharmacother. [2006] 40(1):53-7).

NeOpuntia (Opuntia ficus-indica) is a patented cactus extract composed of soluble and insoluble dietary fibers. These fibers are claimed to bind dietary fat and thus prevent it from being absorbed in the gastrointestinal tract. There are no reported side effects in using NeOpuntia. As with all other natural fibers it is important to drink 2 to 3 quarts (2-3 liters) of water daily while using NeOpuntia. Pregnant and nursing women should not use NeOpuntia.

Phase 2 is extracted from white kidney beans. It has been shown clinically that it can neutralize the digestive enzyme alpha amylase, stopping it from converting carbohydrate into glucose and subsequently fat. In the clinical studies on Phase 2, one of the principal side effects reported was excessive gas. Other side effects included anxiety or restlessness.

ForsLean (Coleus forskholii) is an herb that has been shown to enhance lipolysis. It may also inhibit fat storage. A clinical study published in the Journal of the International Society of Sports Nutrition (2005: 2(2): 54-62) indicated that there were no significant side effects – despite previous research indicating that Coleaus forskohlii may cause an increase in heart rate and decrease in blood pressure.

7-Keto-DHEA is a naturally occurring metabolite of DHEA, a steroid hormone produced in the body, and believed to enhance metabolism. Because 7-keto-DHEA cannot trigger potentially dangerous levels of estrogen and testosterone in the body, which can occur in some patients who use DHEA, scientists now consider that 7-keto DHEA may be a safer alternative.

ChromeMate (Chromium Polynicotinate) is a niacin-bound chromium complex that plays an important role in the regulation of insulin function, and the maintenance of healthy blood sugar and cholesterol levels. Chromium has reported side effects, even when taken in low doses of 200-400 mcg per day. These side effects include headaches, insomnia and sleep disturbances. Irritability, mood change, and some weight gain may also occur. There have been cognitive, perceptual and motor dysfunction reported in some extreme cases. A high dose of chromium, 600-2400 mcg per day, may cause anemia, thrombocytopenia, hemolysis, hepatic dysfunction and renal failure.

Bioperine is a standardized extract from the fruit of Piper nigrum L (black pepper), or Piper longum L (long pepper), that contains 95 percent Piperine. Piperine, in the patented form of Bioperine increases the body’s natural thermogenic activity. It also enhances the body’s absorption of nutrients. No significant Bioperine side effects have been reported so far. Minor gastrointestinal discomfort or GI symptoms may occur with high doses of Bioperine. It is possible that the use of Bioperine may increase the side effects of certain supplements or drugs due to increased absorption. Studies have not been carried out to determine the side effects of chronic supplementation with Bioperine.

PinnoThin (Korean Pine Nut Oil) is included in the Liporexall formulation as an appetite suppressant due to the fact that it is believed to stimulate several appetite suppressing hormones (cholecystokinin and glucagon-like peptide 1). In a clinical study (Lipids Health Dis. 2008: 28;6) 2000 mg of Pinnothin taken 30 minutes before a buffet lunch reduced food intake by 9% (50 calories). Clinical studies have shown that there are no known side effects associated with Korean pine nut oil. However, like many other ingredients it could potentially cause allergic reactions.

Infinergy Caffeine Malate delivers an energy boost, as well as promoting modest thermogenic activity. It is a common ingredient in many weight loss products and diet pills. Infinergy Caffeine Malate is a modified form of caffeine (it is bonded with malic acid). It is stimulants such as caffeine that can cause headaches, insomnia, jitteriness, diarrhea, irregular heartbeat, dizziness, vomiting, loss of appetite, raised blood pressure and increased heart rate.claimed to outperform regular caffeine. However, there is no published data to validate these claims.

Liporexall dosage

One capsule of Liporexall is taken 2 times per day to a total dose of 921 mg. Each bottle contains 60 capsules and lasts 30 days (2 capsules/day).

Lipo-6 is a weight loss supplement that can be used by both men and women. It has a relatively high content of the stimulants Caffeine, Yohimbe and Synephrine. Side effects that have been reported using Lipo-6 include: Dizziness, headache, insomnia, anxiety, diarrhea, increased heart rate, cold sweats, shortness of breath, cough and itchy skin.

See also: Lipo-6 review

Lipo-6 dosage

Lipo-6 comes in two sizes, a 120 capsule and a 240 capsule bottle. The 120 capsule bottle will last the average individual about 30 days, whereas the 240 will last about 60 days. The recommended dosage of Lipo-6 is four liquid capsules per day (two taken 30 minutes prior to breakfast and two in the afternoon). Lipo-6 should be taken progressively to assess tolerance.

Lipo-6 ingredients

The active ingredients in two capsules (one serving) of Lipo-6 are Synephrine HCL (20 mg), Guggulsterones E and Z (20 mg), Yohimbine HCL (3 mg), Bioperine (5 mg) and caffeine (200 mg). The other ingredients in Lipo-6 are Oleic Acid, Gelatin and Sesame Oil.

Synephrine HCL: Synephrine is sourced from the Citrus aurantium plant. It can help promote fat burning, suppress appetite and increase energy. However, clinical studies have revealed that Citrus aurantium stimulates a relatively small increase in thermogenesis. Reported side effects of Synephrine include dry mouth, headache, nervousness, anxiety, insomnia, tremor, blurred vision, increased heart rate and blood pressure. Synephrine may also reduce the ability to urinate. It is advisable to consult a doctor if you have any history of high blood pressure, anxiety, urinary problems or cardiac disease. In addition, combining decongestants such as Synephrine with other medicines with similar side effects may lead to dangerous complications.

Caffeine: This compound is incorporated into many weight loss supplements available today. Caffeine can cause anxiety, jitters, headaches, diarrhea, insomnia and increased heart rate.

GuggulEZ100: This ingredient is a patented extract of Commiphora mukul. Other common names for GuggulEZ100 are Gugalipids and Guggul. Studies have concluded that Guggal is safe and effective in lowering the various lipid fractions that are known to contribute to coronary heart disease. There is some clinical evidence to suggest that Guggul may promote fat burning (e.g. J Postgrad Med. 1995;41(1):5-7) by stimulating the secretion of the thyroid T3 hormone.

Bioperine: This ingredient is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). Bioperine has been demonstrated in clinical studies to increase the absorption of ingredients in nutritional supplement formulations. Additional absorption may not necessarily be beneficial. It is possible that the use of Bioperine may increase the side effects of certain supplements or drugs due to increased absorption. Minor gastrointestinal discomfort or GI symptoms may occur with high doses of Bioperine.

Yohimbe: This is a tree bark containing a variety of pharmacologically active chemicals. A number of studies support Yohimbe’s positive effect on weight loss (e.g. Isr J Med SCI 1991. 27(10):550-6). However, its effects are not dramatic. Serious side effects associated with products containing Yohimbe have been reported to the FDA, including renal failure, seizures and death. The major alkaloid in Yohimbe is Yohimbine, a chemical that induces vasodilation, thereby lowering blood pressure. Yohimbine is also used as a prescription drug in the United States. Additional side effects may include central nervous system stimulation that causes anxiety attacks. At high doses, Yohimbine acts as a monoamine oxidase (MAO) inhibitor. MAO inhibitors can cause serious adverse effects when taken in combination with tyramine-containing foods (e.g. liver, cheese and red wine) or with over-the-counter (OTC) products containing phenylpropanolamine, such as nasal decongestants and diet products. Individuals taking Yohimbe are warned to avoid these foods and OTC products because of the increased likelihood of adverse effects. Yohimbe should also be avoided by individuals suffering from hypotension (low blood pressure), diabetes, and heart, liver or kidney disease. Symptoms of overdose include weakness and nervous stimulation followed by paralysis, fatigue, stomach disorders and ultimately death.

Lipo-6 conclusion

Although Lipo-6 no longer contains ephedra it remains a stimulant heavy diet pill. If sensitive to stimulants, this is a weight loss product best avoided. However, there are many positive testimonials from people that have lost weight using Lipo-6, particularly those following sensible diet and exercise routines.

Qnexa is a proprietary drug formulation that incorporates the active ingredients from two previously approved products with proven weight loss properties – phentermine and topiramate. By combining the activity of each of these compounds in a once-daily, low-dose capsule formulation, Qnexa simultaneously targets appetite and satiety. The weight loss observed with Qnexa in the EQUIP and CONQUER clinical trials exceeded the weight loss observed for other agents reported in scientific literature. The most common side effects of Qnexa are itching, dry mouth, altered taste and constipation.

See also: Qnexa Review

Phentermine has been available for treating obesity since the 1950s and is still the most widely prescribed weight loss drug. Topiramate was approved in 1996 for treating epilepsy, and more recently as a prophylactic for migraine. The rationale behind Qnexa is to expand topiramate’s therapeutic window by using a low dose and combining it with phentermine. Topiramate works via GABA and other agonist properties and increases the sensation of fullness or satiety, while phentermine is noradrenergic and non-serotonergic, and reduces appetite.

Phentermine is released into the body immediately and helps reduce appetite. It was a major component of the recalled diet drug fen-phen, which was linked to heart and lung problems and was taken off the market ion 1997. Topiramate is time released and used in very low doses to give patients a feeling of satiety.

Side effects of Qnexa

Qnexa is claimed by the manufacturer to be well tolerated. The most common side effects are itching, dry mouth, altered taste and constipation.

Reported drug-related adverse events for depression and altered mood were 1.9% for full-dose Qnexa, 0.9% for the mid-dose and 1.8% for placebo patients.

The most common side effects reported by patients given a half-dose of Qnexa (7.5 mg of phentermine plus 46 mg of Topamax) or a full-dose of Qnexa (15 mg of phentermine plus 92 mg of Topamax) were:

• 15-20% reported a feeling of “pins and needles” on the skin versus 3% in the placebo group
• 12-18% reported dry mouth versus 0% in the placebo group
• 8-15% reported altered taste versus 0% in the placebo group
• 6-11% reported constipation versus 6 percent in the placebo group
• 0.9-1.9% reported depression and altered mood versus 1.8 percent in the placebo group

Qnexa and depression

Depression, or depressed mood adverse events of a moderate to severe nature, were less than 2% and were similar among patients in the Qnexa and placebo groups.

Qnexa and behaviour change and suicide attempts

There were no suicide attempts or suicidal behaviors, and there was no signal for suicidal ideation across all Qnexa treatment groups including the placebo. The US Food and Drug Administration (FDA) previously put out a warning that Topamax (topiramate) increases the risk of suicidal thoughts.

Qnexa discontinuation rates

Overall in clinical studies, discontinuation rates due to adverse cognitive events were low and the events were generally mild to moderate and reversible with discontinuation of treatment. There was one severe event in the treatment arm and one in the placebo arm that led to discontinuation. Discontinuation rates for these various cognitive-related events were low and all occurred at a frequency of less than 1%. This rate is considerably lower than the 3% discontinuation rate reported for Topamax (topiramate).

Qnexa ingredients

Qnexa is a propriety formulation. The key ingredients are topiramate and phentermine.

Qnexa is currently being evaluated in clinical studies at 3 different doses:

• Full strength: 92mg of topiramate/15 mg of phentermine
• Mid dose: 46mg of topiramate/7.5mg of phentermine
• Low dose: 23 mg of topiramate/3.75mg of phentermine

Reference

Press Releases from Vivus Inc. http://ir.vivus.com

Considerable doubt remains as to the purity of Zhen de Shou diet pills. The so called original Zhen de Shou diet pills are believed by many to contain Sibutramine, while the fake ones have also been shown to contain Ephedra and other damaging substances.

Sibutramine, also known as Meridia and Reductil, is a licensed prescription drug used for the treatment of obesity. Ephedra containing products are banned in North America and Europe.

What is Zhen de Shou?

Zhen de Shou is a Chinese manufactured weight loss supplement that promises significant weight loss in a short amount of time. Numerous potentially dangerous fake versions can be found on the market. Current reports indicate five known imitations of Zhen de Shou. Its primary promoter and retail agent is Magic Potions (www.magic-potions.com), a company that sells a number of products designed for health and wellness as well as beauty products.

Zhen de Shou is designed to suppress appetite and increase metabolism in order to facilitate weight loss. Zhen de Shou also stimulates thirst, leading to an increased intake of liquids. This is believed to help flush out toxins.

Ingredients of Zhen de Shou

The primary ingredients in Zhen de Shou are said to be sourced from an area of China known as Shennong’s Ladder or Shennongjia. This is a National Reserve forest in which around 1300 medicinal plants grow.

Zhen de Shou contains:

Crataegus Pinnatifida, which is also known as Shenxianye or Fairy Leaves, is believed to increase metabolism and help promote fat loss. Konjac, the active ingredient in this plant, is used to restrict the absorption of fat from the intestinal tract by limiting lipase activity. As a result, more dietary fat is discharged from the body as waste.

Zhen de Shou also contains safflower, gingko-nut, cassia, alga (luoxuanxao) and konjacflour.

Sibutramine in Zhen de Shou

Sibutramine is a serotonin reuptake inhibitor. It is the neurotransmitter in the brain responsible for generating the feeling of satiety. Sibutramine works by preventing the reuptake of serotonin and norepinephrine. Since the serotonin is not being removed from the body, appetite is effectively suppressed. Elevated levels of norepinephrine, due to the presence of sibutramine, help boost energy.

Side Effects of Zhen de Shou

Side effects in slimmers taking Zhen de Shou diet pills have led to a recall of the product within the US by the FDA. Pills were found to contain sibutramine, an ingredient that is not listed on the product label.

Not declaring sibutramine as an ingredient in Zhen de Shou poses serious health risks. This drug can significantly increase both blood pressure and pulse rate. Some say that the original product does not produce these side effects and that the side effects have been attributed to an imitation brand. This has resulted in appreciable controversy – Does a pure version of Zhen de Shou actually exist? It is difficult to tell because Zhen de Shou diet pills do not carry certified verification of ingredients and purity from a reputable analytical laboratory.

People with the following medical conditions, or taking certain prescription drugs, should not take sibutramine: hypertension; hyperthyroidism; heart/coronary disease; liver/kidney disease; epilepsy/seizures; bleeding/clotting problems; glaucoma; gallstones; bulimia; depression; drugs that affect the serotonin/norepinephrine levels in the brain such as antidepressants (e.g. Prozac).

Recommended dosage of Zhen de Shou

Each pack contains 10 capsules (250 mg/capsule). A single capsule is taken once daily 30 minutes before breakfast.

FDA recall of Zhen de Shou

All lots of Zhen de Shou Fat Loss Capsules sold in 10 count blister cards are being recalled by Fashion Sanctuary, a major retailer of the product, in conjunction with the FDA.

The diet capsules are being recalled because they have been found to contain sibutramine. This makes Zhen de Shou an unapproved drug. Sibutramine is an FDA approved drug used as an appetite suppressant for weight loss. However, because the drug is not listed on the package label, there is a potential threat to consumers because sibutramine is known to substantially increase blood pressure and/or pulse rate in some patients and may present a significant risk for patients with a history of coronary artery disease, congestive heart failure, arrhythmias or stroke.

The capsules are mainly sold in the US, via the Internet. They are packaged in a box with an inner foil pouch. Inside the pouch is a blister pack containing light and dark green capsules. This recall affects all lot codes and use by dates.

The One Week Health Diet by One Week Health offers rapid weight loss in as little as one week by drinking liquid meals. Very little information is available on the One Week Health Diet website (oneweek.co.uk). Unfortunately the actual ingredients in the liquid meals (plant juice) are not disclosed. This is a cause for concern.

The One Week Health Diet is a diet plan that has two components:

1. Liquid meals taken as a replacement of breakfast and an afternoon snack.

2. The One Week Health Diet Plan must be followed in combination with the liquid meals.

Key features of the One Week Diet System

• Liquid vegetable meal replacements (breakfast and afternoon snack)

• Diet plan with recipes is included in the package

• One Week Diet System is a body detoxifying program

• Ingredients in the One Week Diet System are not disclosed (merely stated to be plant extracts)

• Average claimed weight loss per month with the One Week Diet System is 5-8 pounds

• The One Week Diet System costs £30 per week

• No clinical studies on the One Week Diet System have been carried out

• No money back guarantee

How does the One Week Health Diet work?

The One Week Health Diet liquid meals are claimed to act as a body detoxifying system. Formulated from plant extracts, the concentrated plant juice is said to be filled with vitamins, amino acids and electrolytes. The weight loss achieved through body cleansing diets usually lasts for a few days. In the first two weeks, users lose water weight and not fat.

It appears that One Week Health Diet has to be used for 1-3 months to lose significant weight. After first 2 weeks of usage, the product has to be taken on alternating weeks. On average (based on customer testimonials and user feedback online) a weight loss of 5-8 pounds in a month is realistic with the One Week Health Diet.

How much does One Week Health Diet cost?

The One Week Health Diet costs £30 a week. In the first month three weeks supply of the product is needed, amounting to £90.

One Week Health Diet side effects

The ingredients in the liquid meals or plant juice are not disclosed. As a consequence, it is not possible to predict potential side effects. The user feedback online is not particularly positive. Many dieters claim that they just lost water weight using the One Week Health Diet. As the product is a body cleansing system, it could potentially cause stomach upsets and diarrhea.

One Week Health Diet conclusion

It is possible to lose 5-8 pounds in a month just by eating healthy and doing some extra exercises such as cycling or brisk walking. The price of  the One Week Health Diet appears very high for the weight loss that can be achieved.

Without clinical trials to endorse the weight loss claims, or even details of what the ingredients are, the One Week Diet System must be used with caution.

One Week Diet System manufacturer contact details

One Week Health Ltd, the manufacturers of the One Week Diet System is a company registered in the United Kingdom under company number 6686767. The Company is incorporated in England & Wales.

European Customer Service: Freephone 0800 731 8299.
Or by e-mail at info@oneweek.co.uk

Warehouse address for any product returns:

One Week Health Ltd.
European Distribution Center
Norra Industrigatan 2
289 32 Knislinge
Sweden

Registered address for all letters:

One Week Health Ltd.
St.James House
13 Kensington Square
London W8 5HD
United Kingdom