Lipo-6 is a weight loss supplement that can be used by both men and women. It has a relatively high content of the stimulants Caffeine, Yohimbe and Synephrine. Side effects that have been reported using Lipo-6 include: Dizziness, headache, insomnia, anxiety, diarrhea, increased heart rate, cold sweats, shortness of breath, cough and itchy skin.
See also: Lipo-6 review
Lipo-6 comes in two sizes, a 120 capsule and a 240 capsule bottle. The 120 capsule bottle will last the average individual about 30 days, whereas the 240 will last about 60 days. The recommended dosage of Lipo-6 is four liquid capsules per day (two taken 30 minutes prior to breakfast and two in the afternoon). Lipo-6 should be taken progressively to assess tolerance.
The active ingredients in two capsules (one serving) of Lipo-6 are Synephrine HCL (20 mg), Guggulsterones E and Z (20 mg), Yohimbine HCL (3 mg), Bioperine (5 mg) and caffeine (200 mg). The other ingredients in Lipo-6 are Oleic Acid, Gelatin and Sesame Oil.
Synephrine HCL: Synephrine is sourced from the Citrus aurantium plant. It can help promote fat burning, suppress appetite and increase energy. However, clinical studies have revealed that Citrus aurantium stimulates a relatively small increase in thermogenesis. Reported side effects of Synephrine include dry mouth, headache, nervousness, anxiety, insomnia, tremor, blurred vision, increased heart rate and blood pressure. Synephrine may also reduce the ability to urinate. It is advisable to consult a doctor if you have any history of high blood pressure, anxiety, urinary problems or cardiac disease. In addition, combining decongestants such as Synephrine with other medicines with similar side effects may lead to dangerous complications.
Caffeine: This compound is incorporated into many weight loss supplements available today. Caffeine can cause anxiety, jitters, headaches, diarrhea, insomnia and increased heart rate.
GuggulEZ100: This ingredient is a patented extract of Commiphora mukul. Other common names for GuggulEZ100 are Gugalipids and Guggul. Studies have concluded that Guggal is safe and effective in lowering the various lipid fractions that are known to contribute to coronary heart disease. There is some clinical evidence to suggest that Guggul may promote fat burning (e.g. J Postgrad Med. 1995;41(1):5-7) by stimulating the secretion of the thyroid T3 hormone.
Bioperine: This ingredient is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). Bioperine has been demonstrated in clinical studies to increase the absorption of ingredients in nutritional supplement formulations. Additional absorption may not necessarily be beneficial. It is possible that the use of Bioperine may increase the side effects of certain supplements or drugs due to increased absorption. Minor gastrointestinal discomfort or GI symptoms may occur with high doses of Bioperine.
Yohimbe: This is a tree bark containing a variety of pharmacologically active chemicals. A number of studies support Yohimbe’s positive effect on weight loss (e.g. Isr J Med SCI 1991. 27(10):550-6). However, its effects are not dramatic. Serious side effects associated with products containing Yohimbe have been reported to the FDA, including renal failure, seizures and death. The major alkaloid in Yohimbe is Yohimbine, a chemical that induces vasodilation, thereby lowering blood pressure. Yohimbine is also used as a prescription drug in the United States. Additional side effects may include central nervous system stimulation that causes anxiety attacks. At high doses, Yohimbine acts as a monoamine oxidase (MAO) inhibitor. MAO inhibitors can cause serious adverse effects when taken in combination with tyramine-containing foods (e.g. liver, cheese and red wine) or with over-the-counter (OTC) products containing phenylpropanolamine, such as nasal decongestants and diet products. Individuals taking Yohimbe are warned to avoid these foods and OTC products because of the increased likelihood of adverse effects. Yohimbe should also be avoided by individuals suffering from hypotension (low blood pressure), diabetes, and heart, liver or kidney disease. Symptoms of overdose include weakness and nervous stimulation followed by paralysis, fatigue, stomach disorders and ultimately death.
Although Lipo-6 no longer contains ephedra it remains a stimulant heavy diet pill. If sensitive to stimulants, this is a weight loss product best avoided. However, there are many positive testimonials from people that have lost weight using Lipo-6, particularly those following sensible diet and exercise routines.