Many of the ingredients in LipoFuze can also be found in another controversial diet pill, Apidexin. The medicinal herbs and other natural ingredients that are typically found in weight loss products need to be present in a potent enough dosage to have any effect. As the proportion of each ingredient in LipoFuze is not disclosed, it is difficult to assess if they present in the required dosages to promote significant weight loss.
The effects of potential interaction between the 14 ingredients in LipoFuze have not been clinically evaluated. Internet reviews indicate that some users have reported headaches, nausea, insomnia, profuse sweating and increased heart rate after taking LipoFuze.
Related article: LipoFuze
Lipofuze is fat burner which contains 6 patented and 4 clinically tested ingredients. The ingredients include:
ThermoDiamine: This ingredient is the patented form of evodiamine, a Chinese fruit that is claimed to burn fat by increasing the body’s production of heat and reducing the body’s ability to store fat. But no studies have been conducted in man so far. To date only an animal-based study has been carried out and there is no clinical data on whether or not evodiamine works in human subjects.
Razberi-K: Also known as raspberry ketone or 4-(4-hydroxyphenyl) butan-2-one, this ingredient is thought to enhance weight loss via the stimulation of norepinephrine. Razberi-K is said to aid fat oxidation, but studies on human beings have not convincingly proved its effectiveness. One study performed on rodents demonstrated that raspberry ketones prevented fat synthesis as well as the rise of blood triglycerides and overall, helped prevent excess weight gain. The chemical structure of raspberry ketone is similar to that of capsaicin and synephrine. Both of these compounds are well documented for their ability to boost thermogenesis through the release of norepinephrine. However, there are health risks with these two ingredients; synephrine has been shown to have dangerous cardiovascular side effects, while capsaicin has been demonstrated to cause gastrointestinal problems in many users. There are no documented side effects related to raspberry ketone consumption.
FucoPure: This is the patented version of fucoxanthin, a seaweed extract. There are a number of studies that demonstrate fucoxanthin’s ability to boost metabolism, but to date, they have all been carried out in pre-clinical studies on animals. It is also proven that, this ingredient cannot be absorbed by human body easily. Additionally, it has been shown clinically that compounds like fucoxanthin have low bioavailability in man (see Br J Nutr. 2008 Aug;100(2):273-7). One gram of seaweed has several times the amount of iodine that most adults require on a daily basis. Therefore, a potential fucoxanthin side effect could include changes in thyroid function due to iodine excess.
ForsLean: ForsLean is derived from the root of Coleaus forskohlii, which is native to warm temperate habitats including India, and is the only known plant source of the natural compound Forskolin. Amongst other effects, this compound is understood to increase lean body mass and help optimize body composition though cAMP (cyclic adenosine monophosphate) activation. A number (but not all) of clinical studies have indicated that Coleaus forskohlii may cause an increase in heart rate and a decrease in blood pressure.
GuggulEZ100: This is a patented extract of Commiphora mukul. Other common names are Gugalipids and Guggul. In India Guggul is used widely for the reduction of blood cholesterol. Guggul lowers cholesterol and triglyceride levels and helps maintain a healthy balance of HDL, the good cholesterol, relative to LDL, the bad cholesterol (the HDL/LDL ratio), thereby protecting against cardiovascular disease and atherosclerosis. A number of studies have investigated the anti-inflammatory potential of Guggul. Researchers concluded that Guggal was safe and highly effective in lowering the various lipid fractions that are known to contribute to coronary heart disease. There is some clinical evidence to suggest that Guggul may promote fat burning (see J Postgrad Med. 1995 Jan-Mar;41(1):5-7) by stimulating the secretion of thyroid T3 hormone.
Green tea: Green tea has been shown to promote some weight loss. However, it needs to be used in relatively high concentration, and contain high levels of catechins. In Lipofuze, the amount of green tea present in the formulation is not indicated. Users sensitive to caffeine could experience any of the following side effects: restlessness, irritability, sleeping problems, tremors, heart palpitations, loss of appetite, upset stomach, nausea, frequent urination and skin rash.
Bioperine: This ingredient is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). It contains 95 percent Piperine. Bioperine has been shown in clinical research to increase the absorption of ingredients in nutritional supplement formulations. Additional absorption, even if true, may or may not necessarily be beneficial. It is possible that the use of Bioperine may increase the side effects of certain supplements due to increased absorption.
Capsaicin: This compound is found in chile peppers. It is believed that capsaicin generates heat in the body thereby boosting the burning of calories. However, it appears that very high doses are required for it to be effective. Severe gastrointestinal side effects have been reported in patients ingesting capsaicin. While rare, serious allergic reactions to capsaicin can occur. Contact a physician immediately should difficulty breathing, skin rash, hives, swelling of the throat, lips, or face, severe dizziness, or itching be experienced.
Synephrine HCL: Synephrine is derived from the Citrus aurantium plant used for a variety of purposes in traditional Chinese medicine. Research indicates that it can act as an effective stimulant. After Ephedra was banned by the F.D.A., diet pill makers sought to discover an equivalent. They thought they had found it with Synephrine and, while Synephrine is effective, there is no research that points to Ephedra and Synephrine being comparable. Synephrine can help burn fat, suppress appetite and increase energy. However, clinical studies have revealed that Citrus aurantium induces a relatively modest increase in thermogenesis. Reported side effects include: increased heart rate and blood pressure, insomnia, nervousness, anxiety, tremor, dry mouth, blurred vision, and headache. Synephrine may also reduce the ability to urinate. Consult a physician if you have any history of cardiac disease, high blood pressure, anxiety, or urinary problems. Also, combining decongestants with other medicines with similar side effects may lead to dangerous complications.
7-OXO DHEA: This compound is a metabolite of DHEA, a steroid hormone. This ingredient has been shown to have a positive effect on thyroid hormone levels in obese people, without apparent side effects (see J Nutr Biochem. 2007; 18(9):629-34. Current Therapeutics, (7):435-442 2000). 7-OXO DHEA has been found to be safe in animals at high doses and in humans at up to 200 mg daily. 7-OXO-DHEA should not be taken if you are being treated with glucocorticoids, as it may interfere with their effectiveness.
Other ingredients in the LipoFuze formulation include cinnamon, phenylethylamine, ginger, and 20-hydroxyecdysone (a plant steroid considered to have anabolic activity in mammals).
Is Lipofuze effective?
User feedback on Lipofuze has varied. Some have reported fast weight loss in the first few days (water loss?) when combined with diet and exercise, but the rate of weight loss is lower than claimed by the manufacturers.