Side Effects of Apidexin


Apidexin is a fat burner that relies on eight ingredients. Many of the ingredients, such as ThermoDiamine, are not found in many diet pills currently on the market. The manufacturers of Apidexin are open about its composition, so that it is possible to research the ingredients beyond the information provided on the website. While many users are happy with the product, some have reported side effects.

Apidexin ingredients

DiCaffeine Malate is a familiar weight-loss ingredient. (The compound may cause jitters, insomnia, headaches, increased heart rate and blood pressure – see below).

ThermoDiamine is fruit-based. (No side effects have been reported).

ForsLean contains Coleaus Forskohlii, which is derived from an Asian plant. (There is some evidence which suggests that Coleaus forskohlii may cause an increase in heart rate and a decrease in blood pressure – see below).

Fucoxanthin is derived from Japanese Wakame seaweed. (Because there have been no clinical studies with Fucoxanthin, potential side effects are not known).

GuggulEZ 100 (Commiphora Mukul). (There are no reported side effects).

Razberi-K is derived from raspberries. (There are no reported side effects).

Lipolide-SC. (There are no reported side effects).

Bioperine, which is an extract from the fruit of Piper nigrum L (black pepper), or Piper longum L (long pepper). It contains 95% piperine. (No significant side effects have been reported at this time. Minor gastrointestinal discomfort or GI symptoms may occur with high doses of Bioperine).

Side effects reported by some users

Reported side effects include sleeplessness. Taking more capsules than the recommended dose can cause jitteriness and nervousness.

Ingredients in detail

DiCaffeine Malate
Originally used by the Coca Cola Company as an alternative to cocaine, DiCaffeine Malate is a stimulant-based ingredient used in soft drinks, energy drinks and dietary supplements. DiCaffeine Malate combines natural caffeine with Malic Acid. The combination forms an ionic bonded compound which is gentle on the stomach, and is claimed to optimize energy, stimulate thermogenesis and increase mental focus.

Many clinical studies validate caffeine as an agent for boosting energy and helping with weight loss. DiCaffeine Malate may cause jitters, insomnia, headaches, increased heart rate and raised blood pressure.

Thermodiamine, also known as Evodiamine, is a quinozole alkaloid isolated from the unripe fruit of Evodia Rutaecarpa. Evodia's main constituents include Evodine, Evodiamine, Dehydroevodiamine and Rutaecarpine.

Thermodiamine appears to support an increase in lipolytic (fat burning) activity through several mechanisms. Similar to the action of Capsaicin (cayenne pepper), Evodiamine appears to affect receptors known as vanilloids. These receptors are involved in the regulation of body temperature. However, it does so without the common side effects of burning and indigestion associated with the use of Capsaicin. Secondly, Evodiamine may support an increased output of Catecholamines like Epinephrine, and Nor-Epinephrine from the adrenals. Since Catecholamines are involved in fat loss, Evodiamine assists in supporting healthy fat oxidation pathways. Lastly, studies suggest Evodiamine may support an increase in peripheral heat loss, while the body's core temperature remains unchanged. No side effects have been reported.

ForsLean is derived from the root of Coleaus forskohlii, which is native to warm temperate habitats including India, and is the only known plant source of the natural compound Forskolin. Amongst other effects, this compound is understood to increase lean body mass and help optimize body composition though cAMP (cyclic adenosine monophosphate) activation. A number (but not all) of clinical studies have indicated that Coleaus forskohlii may cause an increase in heart rate and decrease in blood pressure.

Fucoxanthin is a type of carotenoid found naturally in edible brown seaweed such as Wakame (Undaria pinnatifida) and Hijiki (Hijikia fusiformis), which are used widely in Asian cuisine. Wakame is the seaweed used in miso soup. Fucoxanthin is also found in much smaller amounts in red seaweed (the kind typically used in Japanese sushi rolls) and green seaweed.

Fucoxanthin is being explored for weight loss. Japanese researchers have found that Fucoxanthin (isolated from Wakame) promotes the loss of abdominal fat in obese mice and rats. Animals lost five to 10% of their body weight. Although it is not fully understood how Fucoxanthin works, it appears to target a protein called UCP1 that increases the rate at which abdominal fat is burned. Abdominal fat, also called white adipose tissue, is the kind of fat that surrounds organs and is linked to heart disease and diabetes. Fucoxanthin also appears to stimulate the production of DHA, one of the omega-3 fatty acids found in fatty fish such as salmon. Because there have been no clinical studies with Fucoxanthin, potential side effects are not known. It should be noted that large amounts of Wakame, or other types of seaweed, should not be consumed as a source of Fucoxanthin. Seaweed is rich in iodine and excessive consumption may result in iodine poisoning. High levels of iodine can interfere with the function of the thyroid gland. Also, consuming excess amounts of iodine-rich foods is not recommended if there is a known allergy or hypersensitivity to iodine.

GuggulEZ 100
GuggulEZ 100 (Commiphora mukul). Other common names: Gugalipids, Guggul. In India Guggul is used widely for the reduction of blood cholesterol. The herb has been used traditionally to treat Cerical Spondylitis, a type of cervical inflammation and arthritis. Guggul lowers cholesterol and triglyceride levels and helps maintain a healthy balance of HDL, the good cholesterol, relative to LDL, the bad cholesterol (the HDL/LDL ratio), thereby protecting against cardiovascular disease and atherosclerosis. A number of studies have investigated the anti-inflammatory potential of Guggul. Researchers concluded that Guggal was safe and highly effective in lowering the various lipid fractions that are known to contribute to coronary heart disease. There are no reported side effects.

Bioperine is a standardized extract from the fruit of Piper nigrum L (black pepper) or Piper longum L (long pepper). It contains 95 percent Piperine. Bioperine has been shown in clinical research to increase the absorption of ingredients in nutritional supplement formulations. Additional absorption, even if true, may or may not necessarily be beneficial. It is possible that the use of Bioperine may increase the side effects of certain supplements due to increased absorption. No significant Bioperine side effects have been reported at this time. Minor gastrointestinal discomfort or GI symptoms may occur with high doses of Bioperine.

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